{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:10:37Z","timestamp":1777590637708,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Rotary International","award":["PP18BMF0002"],"award-info":[{"award-number":["PP18BMF0002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The polio eradication endgame called for the removal of trivalent oral poliovirus vaccine (OPV) and introduction of bivalent (types 1 and 3) OPV and inactivated poliovirus vaccine (IPV). However, supply shortages have delayed IPV administration to tens of millions of infants, and immunogenicity data are currently lacking to guide catch-up vaccination policies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted an open-label randomized clinical trial assessing 2 interventions, full or fractional-dose IPV (fIPV, one-fifth of IPV), administered at age 9\u201313 months with a second dose given 2 months later. Serum was collected at days 0, 60, 67, and 90 to assess seroconversion, priming, and antibody titer. None received IPV or poliovirus type 2-containing vaccines before enrolment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A single fIPV dose at age 9\u201313 months yielded 75% (95% confidence interval [CI], 6%\u201382%) seroconversion against type 2, whereas 2 fIPV doses resulted in 100% seroconversion compared with 94% (95% CI, 89%\u201397%) after a single full dose (P &amp;lt; .001). Two doses of IPV resulted in 100% seroconversion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study confirmed increased IPV immunogenicity when administered at an older age, likely due to reduced interference from maternally derived antibodies. Either 1 full dose of IPV or 2 doses of fIPV could be used to vaccinate missed cohorts, 2 fIPV doses being antigen sparing and more immunogenic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trial Registration<\/jats:title>\n                  <jats:p>NCT03890497.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiac205","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T09:46:10Z","timestamp":1652694370000},"page":"1319-1326","source":"Crossref","is-referenced-by-count":8,"title":["One Full or Two Fractional Doses of Inactivated Poliovirus Vaccine for Catch-up Vaccination in Older Infants: A Randomized Clinical Trial in Bangladesh"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0203-5744","authenticated-orcid":false,"given":"Asma B","family":"Aziz","sequence":"first","affiliation":[{"name":"International Centre for Diarrheal Disease, Bangladesh , Dhaka , Bangladesh"},{"name":"International Vaccine Institute , Seoul , South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish","family":"Verma","sequence":"additional","affiliation":[{"name":"World Health Organization , Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Visalakshi","family":"Jeyaseelan","sequence":"additional","affiliation":[{"name":"World Health Organization , Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Yunus","sequence":"additional","affiliation":[{"name":"International Centre for Diarrheal Disease, Bangladesh , Dhaka , Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samarea","family":"Nowrin","sequence":"additional","affiliation":[{"name":"International Centre for Diarrheal Disease, Bangladesh , Dhaka , Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah D","family":"Moore","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo A","family":"Mainou","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ondrej","family":"Mach","sequence":"additional","affiliation":[{"name":"World Health Organization , Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland W","family":"Sutter","sequence":"additional","affiliation":[{"name":"World Health Organization , Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalequ","family":"Zaman","sequence":"additional","affiliation":[{"name":"International Centre for Diarrheal Disease, Bangladesh , Dhaka , Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"2022101708573541500_jiac205-B1","author":"Centers for Disease Control and Prevention","year":"2021"},{"key":"2022101708573541500_jiac205-B2","author":"Rotary District 9820"},{"key":"2022101708573541500_jiac205-B3","author":"Global Polio Eradication Initiative"},{"key":"2022101708573541500_jiac205-B4","author":"Global Polio Eradication Initiative"},{"key":"2022101708573541500_jiac205-B5","author":"Global Commission for the Certification of the Eradication of Poliomyelitis"},{"key":"2022101708573541500_jiac205-B6","author":"Global Polio Eradication Initiative"},{"key":"2022101708573541500_jiac205-B7","author":"Global Polio Eradication Initiative"},{"key":"2022101708573541500_jiac205-B8","author":"Global Polio Eradication 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