{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:58:03Z","timestamp":1792097883443,"version":"4.4.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"GlaxoSmithKline Biologicals, SA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The true burden of lower respiratory tract infections (LRTIs) due to respiratory syncytial virus (RSV) remains unclear. This study aimed to provide more robust, multinational data on RSV-LRTI incidence and burden in the first 2 years of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, observational cohort study was conducted in Argentina, Bangladesh, Canada, Finland, Honduras, South Africa, Thailand, and United States. Children were followed for 24 months from birth. Suspected LRTIs were detected via active (through regular contacts) and passive surveillance. RSV and other viruses were detected from nasopharyngeal swabs using PCR-based methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2401 children, 206 (8.6%) had 227 episodes of RSV-LRTI. Incidence rates (IRs) of first episode of RSV-LRTI were 7.35 (95% confidence interval [CI], 5.88\u20139.08), 5.50 (95% CI, 4.21\u20137.07), and 2.87 (95% CI, 2.18\u20133.70) cases\/100 person-years in children aged 0\u20135, 6\u201311, and 12\u201323 months. IRs for RSV-LRTI, severe RSV-LRTI, and RSV hospitalization tended to be higher among 0\u20135 month olds and in lower-income settings. RSV was detected for 40% of LRTIs in 0\u20132 month olds and for approximately 20% of LRTIs in older children. Other viruses were codetected in 29.2% of RSV-positive nasopharyngeal swabs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A substantial burden of RSV-LRTI was observed across diverse settings, impacting the youngest infants the most.<\/jats:p><jats:p>Clinical Trials Registration. NCT01995175.<\/jats:p><\/jats:sec>","DOI":"10.1093\/infdis\/jiac227","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T05:42:10Z","timestamp":1654580530000},"page":"374-385","source":"Crossref","is-referenced-by-count":43,"title":["Incidence of Respiratory Syncytial Virus Lower Respiratory Tract Infections During the First 2 Years of Life: A Prospective Study Across Diverse Global Settings"],"prefix":"10.1093","volume":"226","author":[{"given":"Joanne M","family":"Langley","sequence":"first","affiliation":[{"name":"Canadian Center for Vaccinology, Dalhousie University, IWK Health and Nova Scotia Health, \u00a0 Halifax, Nova Scotia , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Bianco","sequence":"additional","affiliation":[{"name":"GSK , Rockville, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B","family":"Domachowske","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, SUNY Upstate Medical University , Syracuse, New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabir A","family":"Madhi","sequence":"additional","affiliation":[{"name":"South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand , Johannesburg , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia K","family":"Stoszek","sequence":"additional","affiliation":[{"name":"GSK , Rockville, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalequ","family":"Zaman","sequence":"additional","affiliation":[{"name":"International Centre for Diarrheal Disease , Dhaka , Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin","family":"Bueso","sequence":"additional","affiliation":[{"name":"DEMEDICA , San Pedro Sula , Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ceballos","sequence":"additional","affiliation":[{"name":"Instituto Medico Rio Cuarto , Rio Cuarto, Cordoba , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Cousin","sequence":"additional","affiliation":[{"name":"Tecnologia en Investigacion , San Pedro Sula , Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulises","family":"D\u2019Andrea","sequence":"additional","affiliation":[{"name":"Instituto Medico Rio Cuarto , Rio Cuarto, Cordoba , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Dieussaert","sequence":"additional","affiliation":[{"name":"GSK , Rockville, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet A","family":"Englund","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, University of Washington , Seattle, Washington , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Gandhi","sequence":"additional","affiliation":[{"name":"GSK , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gruselle","sequence":"additional","affiliation":[{"name":"GSK , Wavre , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerco","family":"Haars","sequence":"additional","affiliation":[{"name":"GSK , Wavre , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Jose","sequence":"additional","affiliation":[{"name":"South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand , Johannesburg , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola P","family":"Klein","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Vaccine Study Center , Oakland, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Leach","sequence":"additional","affiliation":[{"name":"GSK , Rockville, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Maleux","sequence":"additional","affiliation":[{"name":"GSK , Wavre , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Lien Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"GSK , Wavre , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanyawee","family":"Puthanakit","sequence":"additional","affiliation":[{"name":"The Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Silas","sequence":"additional","affiliation":[{"name":"Wee Care Pediatrics , Syracuse, Utah , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auchara","family":"Tangsathapornpong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Thammasat University , Pathum Thani , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamaree","family":"Teeratakulpisarn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Khon Kaen University , Khon Kaen , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Vesikari","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, University of Tampere , Tampere , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A","family":"Cohen","sequence":"additional","affiliation":[{"name":"GSK , Rockville, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"2022100316183928400_jiac227-B1","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 2017; 282, causes of death in 195 countries and territories, 1980\u20132017: a systematic analysis for the global burden of disease study 2017","volume":"392","author":"GBD 2017 Causes of Death Collaborators","year":"2018","journal-title":"Lancet"},{"key":"2022100316183928400_jiac227-B2","article-title":"The global health observatory: causes of child death","author":"World Health Organization"},{"key":"2022100316183928400_jiac227-B3","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S0140-6736(17)30938-8","article-title":"Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study","volume":"390","author":"Shi","year":"2017","journal-title":"Lancet"},{"key":"2022100316183928400_jiac227-B4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/ppul.23570","article-title":"Respiratory syncytial virus hospitalization and mortality: systematic review and meta-analysis","volume":"52","author":"Stein","year":"2017","journal-title":"Pediatr Pulmonol"},{"key":"2022100316183928400_jiac227-B5","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(19)30721-4","article-title":"Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study","volume":"394","author":"Pneumonia Etiology Research for Child Health (PERCH) Study Group","year":"2019","journal-title":"Lancet"},{"key":"2022100316183928400_jiac227-B6","doi-asserted-by":"crossref","first-page":"S577","DOI":"10.1093\/infdis\/jiz059","article-title":"Global disease burden estimates of respiratory syncytial virus-associated acute respiratory infection in older adults in 2015: a systematic review and meta-analysis","volume":"222","author":"Shi","year":"2020","journal-title":"J Infect Dis"},{"key":"2022100316183928400_jiac227-B7","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1093\/infdis\/jiaa751","article-title":"Risk Factors for Poor Outcome or Death in Young Children With Respiratory Syncytial Virus\u2013Associated Acute Lower Respiratory Tract Infection: A Systematic Review and Meta-Analysis","volume":"226","author":"Shi","year":"2022","journal-title":"J Infect Dis"},{"key":"2022100316183928400_jiac227-B8","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1017\/S0950268820000400","article-title":"The burden of respiratory syncytial virus in adults: a systematic review and meta-analysis","volume":"148","author":"Tin Tin Htar","year":"2020","journal-title":"Epidemiol Infect"},{"key":"2022100316183928400_jiac227-B9","doi-asserted-by":"crossref","first-page":"e371","DOI":"10.3928\/19382359-20180816-01","article-title":"Preventing pediatric respiratory syncytial virus infection","volume":"47","author":"Domachowske","year":"2018","journal-title":"Pediatr Ann"},{"key":"2022100316183928400_jiac227-B10","doi-asserted-by":"crossref","first-page":"020431","DOI":"10.7189\/jogh.09.020431","article-title":"Respiratory syncytial virus in the Western Pacific region: a systematic review and meta-analysis","volume":"9","author":"Pangesti","year":"2019","journal-title":"J Glob Health"},{"key":"2022100316183928400_jiac227-B11","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3390\/jpm11050416","article-title":"Prevalence and risk factors of respiratory syncytial virus in children under 5 years of age in the WHO European region: a systematic review and meta-analysis","volume":"11","author":"Suleiman-Martos","year":"2021","journal-title":"J Pers Med"},{"key":"2022100316183928400_jiac227-B12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.vaccine.2015.05.093","article-title":"WHO consultation on respiratory syncytial virus vaccine development report from a World Health Organization meeting held on 23\u201324 March 2015","volume":"34","author":"Modjarrad","year":"2016","journal-title":"Vaccine"},{"key":"2022100316183928400_jiac227-B13","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1067\/mpd.2000.110531","article-title":"Rates of hospitalization for respiratory syncytial virus infection among children in Medicaid","volume":"137","author":"Boyce","year":"2000","journal-title":"J Pediatr"},{"key":"2022100316183928400_jiac227-B14","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1136\/adc.88.12.1065","article-title":"The clinical and health economic burden of respiratory syncytial virus disease among children under 2 years of age in a defined geographical area","volume":"88","author":"Deshpande","year":"2003","journal-title":"Arch Dis Child"},{"key":"2022100316183928400_jiac227-B15","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMoa0804877","article-title":"The burden of respiratory syncytial virus infection in young children","volume":"360","author":"Hall","year":"2009","journal-title":"N Engl J Med"},{"key":"2022100316183928400_jiac227-B16","doi-asserted-by":"crossref","first-page":"e437","DOI":"10.1542\/peds.2004-0049","article-title":"Respiratory syncytial virus hospitalizations among American Indian and Alaska Native infants and the general United States infant population","volume":"114","author":"Holman","year":"2004","journal-title":"Pediatrics"},{"key":"2022100316183928400_jiac227-B17","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1542\/peds.113.6.1758","article-title":"Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children","volume":"113","author":"Iwane","year":"2004","journal-title":"Pediatrics"},{"key":"2022100316183928400_jiac227-B18","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1017\/S0950268803008926","article-title":"Hospitalization for respiratory syncytial virus in the paediatric population in Spain","volume":"131","author":"Vicente","year":"2003","journal-title":"Epidemiol Infect"},{"key":"2022100316183928400_jiac227-B19","first-page":"98","article-title":"A simplified general method for cluster-sample surveys of health in developing countries","volume":"44","author":"Bennett","year":"1991","journal-title":"World Health Stat Q"},{"key":"2022100316183928400_jiac227-B20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1086\/524019","article-title":"Respiratory syncytial virus infection and disease in infants and young children observed from birth in Kilifi District, Kenya","volume":"46","author":"Nokes","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2022100316183928400_jiac227-B21","doi-asserted-by":"crossref","first-page":"e1031","DOI":"10.1016\/S2214-109X(19)30264-5","article-title":"Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis","volume":"7","author":"Li","year":"2019","journal-title":"Lancet Glob Health"},{"key":"2022100316183928400_jiac227-B22","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/irv.12885","article-title":"Defining the seasonality of respiratory syncytial virus around the world: national and subnational surveillance data from 12 countries","volume":"15","author":"Staadegaard","year":"2021","journal-title":"Influenza Other Respir Viruses"},{"key":"2022100316183928400_jiac227-B23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1542\/peds.2014-1665","article-title":"Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection","volume":"134","author":"American Academy of Pediatrics Committee on Infectious Diseases, American Academy of Pediatrics Bronchiolitis Guidelines Committee","year":"2014","journal-title":"Pediatrics"},{"key":"2022100316183928400_jiac227-B24","article-title":"Synagis: summary of the European public assessment report","author":"European Medicines Agency"},{"key":"2022100316183928400_jiac227-B25","doi-asserted-by":"crossref","first-page":"e1644","DOI":"10.1016\/S2214-109X(21)00455-1","article-title":"Respiratory syncytial virus: promising progress against a leading cause of pneumonia","volume":"9","author":"Ginsburg","year":"2021","journal-title":"Lancet Glob Health"},{"key":"2022100316183928400_jiac227-B26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1056\/NEJMoa1913556","article-title":"Single-dose nirsevimab for prevention of RSV in preterm infants","volume":"383","author":"Griffin","year":"2020","journal-title":"N Engl J Med"},{"key":"2022100316183928400_jiac227-B27","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax2466","article-title":"Priorities for developing respiratory syncytial virus vaccines in different target populations","volume":"12","author":"Drysdale","year":"2020","journal-title":"Sci Transl Med"},{"key":"2022100316183928400_jiac227-B28","doi-asserted-by":"crossref","first-page":"7355","DOI":"10.1016\/j.vaccine.2017.02.068","article-title":"Meeting report: WHO consultation on respiratory syncytial virus (RSV) vaccine development. Geneva: 25\u201326 April 2016","volume":"37","author":"Giersing","year":"2019","journal-title":"Vaccine"},{"key":"2022100316183928400_jiac227-B29","article-title":"RSV vaccine and mAb snapshot","author":"PATH"},{"key":"2022100316183928400_jiac227-B30","doi-asserted-by":"crossref","first-page":"e1788","DOI":"10.1097\/MD.0000000000001788","article-title":"Respiratory syncytial virus coinfections with rhinovirus and human bocavirus in hospitalized children","volume":"94","author":"Calvo","year":"2015","journal-title":"Medicine"},{"key":"2022100316183928400_jiac227-B31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2334-13-41","article-title":"Severe lower respiratory tract infection in infants and toddlers from a non-affluent population: viral etiology and co-detection as risk factors","volume":"13","author":"da Silva","year":"2013","journal-title":"BMC Infect Dis"},{"key":"2022100316183928400_jiac227-B32","first-page":"443","article-title":"Severity of respiratory syncytial virus lower respiratory tract infection with viral coinfection in HIV-uninfected children","volume":"64","author":"Mazur","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2022100316183928400_jiac227-B33","doi-asserted-by":"crossref","first-page":"010426","DOI":"10.7189\/jogh.10.010426","article-title":"The role of viral co-infections in the severity of acute respiratory infections among children infected with respiratory syncytial virus (RSV): a systematic review and meta-analysis","volume":"10","author":"Li","year":"2020","journal-title":"J Glob Health"},{"key":"2022100316183928400_jiac227-B34","doi-asserted-by":"crossref","first-page":"2001600","DOI":"10.2807\/1560-7917.ES.2021.26.29.2001600","article-title":"Decline of influenza and respiratory syncytial virus detection in facility-based surveillance during the COVID-19 pandemic, South Africa. January to October 2020","volume":"26","author":"Tempia","year":"2021","journal-title":"Euro Surveill"},{"key":"2022100316183928400_jiac227-B35","doi-asserted-by":"crossref","first-page":"2100639","DOI":"10.2807\/1560-7917.ES.2021.26.29.2100639","article-title":"Low levels of respiratory syncytial virus activity in Europe during the 2020\/21 season: what can we expect in the coming summer and autumn\/winter?","volume":"26","author":"van Summeren","year":"2021","journal-title":"Euro Surveill"},{"key":"2022100316183928400_jiac227-B36","doi-asserted-by":"crossref","first-page":"30547","DOI":"10.1073\/pnas.2013182117","article-title":"The impact of COVID-19 nonpharmaceutical interventions on the future dynamics of endemic infections","volume":"117","author":"Baker","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022100316183928400_jiac227-B37","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.3201\/eid2711.211565","article-title":"Resurgence of respiratory syncytial virus infections during COVID-19 pandemic, Tokyo, Japan","volume":"27","author":"Ujiie","year":"2021","journal-title":"Emerg Infect Dis"},{"key":"2022100316183928400_jiac227-B38","doi-asserted-by":"crossref","DOI":"10.4414\/SMW.2021.w30057","article-title":"Interseasonal RSV infections in Switzerland\u2014rapid establishment of a clinician-led national reporting system (RSV EpiCH)","volume":"151","author":"von Hammerstein","year":"2021","journal-title":"Swiss Med Wkly"},{"key":"2022100316183928400_jiac227-B39","article-title":"RSV: The year the respiratory infection \u201ctook its gloves off\u201d","volume":"374","author":"Limb","year":"2021","journal-title":"BMJ"},{"key":"2022100316183928400_jiac227-B40","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1038\/s41467-022-30485-3","article-title":"Off-season RSV epidemics in Australia after easing of COVID-19 restrictions","volume":"; 13","author":"Eden","year":"2022","journal-title":"Nat Commun"},{"key":"2022100316183928400_jiac227-B41","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2021-052089","article-title":"Delayed seasonal RSV surge observed during the COVID-19 pandemic","volume":"148","author":"Agha","year":"2021","journal-title":"Pediatrics"},{"key":"2022100316183928400_jiac227-B42","article-title":"Increased interseasonal respiratory syncytial virus (RSV) activity in parts of the Southern United States","author":"Centers for Disease Control and Prevention, Health Alert Network"},{"issue":"398","key":"2022100316183928400_jiac227-B43","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/S0140-6736(21)01787-6","article-title":"The 2021 report of the lancet countdown on health and climate change: code red for a healthy future","author":"Romanello","year":"2021","journal-title":"Lancet"},{"key":"2022100316183928400_jiac227-B44","doi-asserted-by":"crossref","first-page":"e005671","DOI":"10.1136\/bmjgh-2021-005671","article-title":"Trends and projections of caesarean section rates: global and regional estimates","volume":"6","author":"Betran","year":"2021","journal-title":"BMJ Glob Health"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiac227\/44857477\/jiac227.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/226\/3\/374\/46333220\/jiac227.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/226\/3\/374\/46333220\/jiac227.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T13:39:23Z","timestamp":1675777163000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/226\/3\/374\/6603520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,7]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,6,7]]},"published-print":{"date-parts":[[2022,8,26]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiac227","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,1]]},"published":{"date-parts":[[2022,6,7]]}}}