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Despite the importance of arenaviruses as potential pandemic pathogens, numerous gaps exist in scientific knowledge pertaining to this diverse family, including gaps in understanding replication, immunosuppression, receptor usage, and elicitation of neutralizing antibody responses, that in turn complicates development of medical countermeasures. A further challenge to the development of medical countermeasures for arenaviruses is the requirement for use of animal models at high levels of biocontainment, where each model has distinct advantages and limitations depending on, availability of space, animals species-specific reagents, and most importantly the ability of the model to faithfully recapitulate human disease. Designation of LASV and JUNV as prototype pathogens can facilitate progress in addressing the public health challenges posed by members of this important virus family.<\/jats:p>","DOI":"10.1093\/infdis\/jiac266","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:18:30Z","timestamp":1697609910000},"page":"S359-S375","source":"Crossref","is-referenced-by-count":35,"title":["The Arenaviridae Family: Knowledge Gaps, Animal Models, Countermeasures, and Prototype Pathogens"],"prefix":"10.1093","volume":"228","author":[{"given":"Kathryn M","family":"Hastie","sequence":"first","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology , La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia I","family":"Melnik","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Tulane University School of Medicine , New Orleans, Louisiana 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