{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:09:27Z","timestamp":1760551767435},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To determine viral dynamics in Omicron breakthrough infections, we measured severe acute respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals. During the first 3 days following the onset of symptoms, viral loads were significantly higher (cycle threshold [Ct], 21.76) in vaccinated compared to boostered (Ct, 23.14) individuals (P = .029). However, by performing a longitudinal analysis on 32 individuals over 14 days, no difference in the viral load trajectory was observed between double-vaccinated and boostered patients. Our results indicate that booster immunization results in a reduction in detectable viral loads without significantly changing viral load dynamics over time.<\/jats:p>","DOI":"10.1093\/infdis\/jiac290","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T12:49:04Z","timestamp":1659185344000},"page":"1721-1725","source":"Crossref","is-referenced-by-count":1,"title":["Viral Load Dynamics in SARS-CoV-2 Omicron Breakthrough Infections"],"prefix":"10.1093","volume":"226","author":[{"given":"Felix","family":"Dewald","sequence":"first","affiliation":[{"name":"Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne , Germany"},{"name":"Center for Molecular Medicine Cologne, University of Cologne , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Detmer","sequence":"additional","affiliation":[{"name":"Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne , Germany"},{"name":"Center for Molecular Medicine Cologne, University of Cologne , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Pirkl","sequence":"additional","affiliation":[{"name":"Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hellmich","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Heger","sequence":"additional","affiliation":[{"name":"Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Hospital Hygiene and Infection Control, University Hospital of Cologne , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne , University of Cologne, Cologne , Germany"},{"name":"German Center for Infection Research, Partner Site Bonn-Cologne , Cologne , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Zweigner","sequence":"additional","affiliation":[{"name":"Department of Hospital Hygiene and Infection Control, University Hospital of Cologne , Cologne , 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