{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:32:42Z","timestamp":1793705562044,"version":"4.5.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"Supplement_4","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We summarize studies of varicella vaccine\u2019s effectiveness for prevention of varicella and lessons learned during the first 25 years of the varicella vaccination program in the United States. One dose of varicella vaccine provided moderate protection (82%\u201385%) against varicella of any severity and high protection (100%) against severe varicella, with some waning of protection over time. The 1-dose program (1995\u20132006) had a substantial impact on the incidence both of varicella and of severe outcomes (71%\u201390% decrease) although it did not prevent low-level community transmission and some outbreaks continued to occur in highly vaccinated populations. Two doses of varicella vaccine improved the vaccine\u2019s effectiveness by at least 10% against varicella of any severity, with further declines in the incidence both of varicella and of severe outcomes as well as in both number and size of outbreaks. There is no evidence for waning of the effectiveness of 2 doses of the vaccine.<\/jats:p>","DOI":"10.1093\/infdis\/jiac299","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T10:52:40Z","timestamp":1661338360000},"page":"S425-S430","source":"Crossref","is-referenced-by-count":41,"title":["The Effectiveness of Varicella Vaccine: 25 Years of Postlicensure Experience in the United States"],"prefix":"10.1093","volume":"226","author":[{"given":"Eugene D","family":"Shapiro","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine , New Haven, Connecticut , USA"},{"name":"Department of Epidemiology of Microbial Diseases, Yale School of Public Health , New Haven, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Marin","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"2022102100075867200_jiac299-B1","first-page":"1145","volume-title":"Vaccines","author":"Gershon","year":"2018","edition":"7th ed"},{"key":"2022102100075867200_jiac299-B2","author":"Merck & Co, Inc","year":"2021"},{"key":"2022102100075867200_jiac299-B3","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1056\/NEJM198405313102201","article-title":"Live attenuated varicella virus vaccine. 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Further observations","volume":"10","author":"Orenstein","year":"1988","journal-title":"Epidemiol Rev"},{"key":"2022102100075867200_jiac299-B7","first-page":"1","article-title":"Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP). 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