{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:25:06Z","timestamp":1781558706798,"version":"3.54.5"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Congenital cytomegalovirus (CMV) infection is the most common infectious cause of birth defects and neurological damage in newborns. Despite a well-established role for natural killer (NK) cells in control of CMV infection in older children and adults, it remains unknown whether fetal NK cells can sense and respond to CMV infection acquired in utero.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we investigate the impact of congenital CMV infection on the neonatal NK-cell repertoire by assessing the frequency, phenotype, and functional profile of NK cells in cord blood samples from newborns with congenital CMV and from uninfected controls enrolled in a birth cohort of Ugandan mothers and infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We find that neonatal NK cells from congenitally CMV infected newborns show increased expression of cytotoxic mediators, signs of maturation and activation, and an expansion of mature CD56\u2212 NK cells, an NK-cell subset associated with chronic viral infections in adults. Activation was particularly prominent in NK cell subsets expressing the Fc\u03b3 receptor CD16, indicating a role for antibody-mediated immunity against CMV in utero.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate that NK cells can be activated in utero and suggest that NK cells may be an important component of the fetal and infant immune response against CMV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trials Registration<\/jats:title>\n                    <jats:p>NCT02793622.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiac307","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T06:09:13Z","timestamp":1658729353000},"page":"566-575","source":"Crossref","is-referenced-by-count":15,"title":["In Utero Activation of Natural Killer Cells in Congenital Cytomegalovirus Infection"],"prefix":"10.1093","volume":"226","author":[{"given":"Anna V","family":"Vaaben","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Levan","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine B T","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perri C","family":"Callaway","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco , San Francisco, California , USA"},{"name":"Infectious Diseases and Immunity Graduate Group, University of California Berkeley , California, Berkeley , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Prahl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Warrier","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felistas","family":"Nankya","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Musinguzi","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Kakuru","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K","family":"Muhindo","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Collaboration , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Dorsey","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses R","family":"Kamya","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Collaboration , Kampala , Uganda"},{"name":"Department of Medicine, Makerere University College of Health Sciences , Kampala , Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2515-2989","authenticated-orcid":false,"given":"Margaret E","family":"Feeney","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco , San Francisco, California , USA"},{"name":"Department of Pediatrics, University of California San Francisco , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"2022090418285510400_jiac307-B1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijid.2013.12.010","article-title":"Systematic review of the birth prevalence of congenital cytomegalovirus infection in developing countries","volume":"22","author":"Lanzieri","year":"2014","journal-title":"Int J Infect 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diseases","volume":"10","author":"Forconi","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"2022090418285510400_jiac307-B41","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.4049\/jimmunol.1303211","article-title":"Cutting edge: NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus","volume":"192","author":"Hendricks","year":"2014","journal-title":"J Immunol"},{"key":"2022090418285510400_jiac307-B42","doi-asserted-by":"crossref","first-page":"14725","DOI":"10.1073\/pnas.1110900108","article-title":"Expansion of a unique CD57+ NKG2Chi natural killer cell subset during acute human cytomegalovirus infection","volume":"108","author":"Lopez-Verg\u00e8s","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"2022090418285510400_jiac307-B43","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35869","article-title":"HLA-E binds to natural killer cell receptors CD94\/NKG2A, B and 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