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Random-effects linear regression models examined the rate of fibrosis change 1\u20132 years before starting HCV treatment, within 1 year before starting (peri-HCV treatment), within 1 year after and 1\u20132 years post-HCV treatment in unadjusted and adjusted models including age, race, and changes from pretreatment of factors that might affect fibrosis (eg, alcohol, integrase strand inhibitor [INSTI] use, waist circumference, CD4 count).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>INSTI use nearly doubled from pre- to peri-HCV treatment. In unadjusted analysis, there was a 3.3% rate of rise in ELF pre-HCV treatment, 2.2% and 3.6% rate of decline during the peri- and 1-year post-HCV treatment period, respectively, followed by a 0.3% rise. Similar findings were observed for APRI and FIB-4. There was little effect on the estimated fibrosis trajectories after adjustment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The apparent lack of decline in biomarkers of liver fibrosis beyond 1 year after HCV cure suggests that continued monitoring of liver fibrosis and interventions to mitigate progression in people with HIV after HCV cure remains essential.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiac315","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T17:45:27Z","timestamp":1660239927000},"page":"1274-1281","source":"Crossref","is-referenced-by-count":10,"title":["Longitudinal Assessment of the Enhanced Liver Fibrosis Score in the Era of Contemporary HIV and Hepatitis C Virus Treatment"],"prefix":"10.1093","volume":"227","author":[{"given":"Annelys Roque","family":"Gardner","sequence":"first","affiliation":[{"name":"Department of Medicine, Emory University , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bacchetti","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer C","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H","family":"Kuniholm","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University at Albany, State University of New York , Rensselaer, New York , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey L","family":"French","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stroger Hospital, Cook County Health , Chicago, Illinois , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7842-512X","authenticated-orcid":false,"given":"Stephen","family":"Gange","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adaora A","family":"Adimora","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina , Chapel Hill, North Carolina , 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