{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:13:14Z","timestamp":1791421994040,"version":"4.3.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"name":"M\u00e9rieux","award":["GDR2073"],"award-info":[{"award-number":["GDR2073"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), along with extensive nonpharmacological interventions, have profoundly altered the epidemiology of major respiratory viruses. Some studies have described virus-virus interactions, particularly manifested by viral interference mechanisms at different scales. However, our knowledge of the interactions between SARS-CoV-2 and other respiratory viruses remains incomplete. Here, we studied the interactions between SARS-CoV-2 and several respiratory viruses (influenza, respiratory syncytial virus, human metapneumovirus, and human rhinovirus) in a reconstituted human epithelial airway model, exploring different scenarios affecting the sequence and timing of coinfections. We show that the virus type and sequence of infections are key factors in virus-virus interactions, the primary infection having a determinant role in the immune response to the secondary infection.<\/jats:p>","DOI":"10.1093\/infdis\/jiac357","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T01:58:18Z","timestamp":1661738298000},"page":"2095-2104","source":"Crossref","is-referenced-by-count":40,"title":["Interactions Between Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Major Respiratory Viruses in Human Nasal Epithelium"],"prefix":"10.1093","volume":"226","author":[{"given":"Andr\u00e9s","family":"Pizzorno","sequence":"first","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Padey","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"},{"name":"Signia Therapeutics SAS , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Duli\u00e8re","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"},{"name":"VirNext, Facult\u00e9 de M\u00e9decine RTH Laennec, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Mouton","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"},{"name":"Laboratoire Commun de Recherche, Hospices Civils de Lyon, bioM\u00e9rieux Centre Hospitalier Lyon Sud , Pierre-B\u00e9nite , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Oliva","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Laurent","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"},{"name":"VirNext, Facult\u00e9 de M\u00e9decine RTH Laennec, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedrine","family":"Milesi","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lina","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelien","family":"Traversier","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"},{"name":"VirNext, Facult\u00e9 de M\u00e9decine RTH Laennec, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Julien","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"},{"name":"VirNext, Facult\u00e9 de M\u00e9decine RTH Laennec, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Trouillet-Assant","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"},{"name":"Laboratoire Commun de Recherche, Hospices Civils de Lyon, bioM\u00e9rieux Centre Hospitalier Lyon Sud , Pierre-B\u00e9nite , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rosa-Calatrava","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , France"},{"name":"VirNext, Facult\u00e9 de M\u00e9decine RTH Laennec, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Terrier","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Team VirPath, Universit\u00e9 de Lyon, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon , Lyon , 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