{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:38:59Z","timestamp":1784173139488,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"DOI":"10.13039\/100019346","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019346","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN261200800001E"],"award-info":[{"award-number":["HHSN261200800001E"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23-AI146268"],"award-info":[{"award-number":["K23-AI146268"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K08-AI139361"],"award-info":[{"award-number":["K08-AI139361"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01-GM130900"],"award-info":[{"award-number":["R01-GM130900"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is limited evidence to evaluate screening algorithms with rapid antigen testing and exposure assessments as identification strategies for paucisymptomatic or asymptomatic Ebola virus (EBOV) infection and unrecognized EBOV disease (EVD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used serostatus and self-reported postexposure symptoms from a cohort study to classify contact-participants as having no infection, paucisymptomatic or asymptomatic infection, or unrecognized EVD. Exposure risk was categorized as low, intermediate, or high. We created hypothetical scenarios to evaluate the World Health Organization (WHO) case definition with or without rapid diagnostic testing (RDT) or exposure assessments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>This analysis included 990 EVD survivors and 1909 contacts, of whom 115 (6%) had paucisymptomatic or asymptomatic EBOV infection, 107 (6%) had unrecognized EVD, and 1687 (88%) were uninfected. High-risk exposures were drivers of unrecognized EVD (adjusted odds ratio, 3.5 [95% confidence interval, 2.4\u20134.9]). To identify contacts with unrecognized EVD who test negative by the WHO case definition, the sensitivity was 96% with RDT (95% confidence interval, 91%\u201399%), 87% with high-risk exposure (82%\u201392%), and 97% with intermediate- to high-risk exposures (93%\u201399%). The proportion of false-positives was 2% with RDT and 53%\u201393% with intermediate- and\/or high-risk exposures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We demonstrated the utility and trade-offs of sequential screening algorithms with RDT or exposure risk assessments as identification strategies for contacts with unrecognized EVD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiac359","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T08:42:40Z","timestamp":1662021760000},"page":"878-887","source":"Crossref","is-referenced-by-count":6,"title":["Identifying Paucisymptomatic or Asymptomatic and Unrecognized Ebola Virus Disease Among Close Contacts Based on Exposure Risk Assessments and Screening Algorithms"],"prefix":"10.1093","volume":"227","author":[{"given":"Dehkontee","family":"Gayedyu-Dennis","sequence":"first","affiliation":[{"name":"Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mosoka P","family":"Fallah","sequence":"additional","affiliation":[{"name":"Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) , Monrovia , Liberia"},{"name":"A.M. Dogliotti College of Medicine, University of Liberia , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Drew","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, University of Minnesota , Minneapolis, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Badio","sequence":"additional","affiliation":[{"name":"Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) , Monrovia , Liberia"},{"name":"Department of Epidemiology and Biostatistics, University of California , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Moses","sequence":"additional","affiliation":[{"name":"Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) , Monrovia , Liberia"},{"name":"Department of Epidemiology and Biostatistics, University of California , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamba","family":"Fayiah","sequence":"additional","affiliation":[{"name":"Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumblytee","family":"Johnson","sequence":"additional","affiliation":[{"name":"Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) , Monrovia , Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene T","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital , Boston, Minnesota , USA"},{"name":"Department of Global Health and Social Medicine, Harvard Medical School , Boston, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7807-4072","authenticated-orcid":false,"given":"Sheri D","family":"Weiser","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Disease, and Global Medicine, Department of Medicine, University of California , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis C","family":"Porco","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California , San Francisco, California , USA"},{"name":"Francis I. Proctor Foundation, University of California , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C","family":"Sneller","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases , Bethesda, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California , San Francisco, California , USA"},{"name":"Institute for Global Health Sciences, University of California , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cavan","family":"Reilly","sequence":"additional","affiliation":[{"name":"Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) , Monrovia , Liberia"},{"name":"Division of Biostatistics, University of Minnesota , Minneapolis, Minnesota , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina P","family":"Lindan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California , San Francisco, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7616-0321","authenticated-orcid":false,"given":"J D","family":"Kelly","sequence":"additional","affiliation":[{"name":"Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) , Monrovia , Liberia"},{"name":"Department of Epidemiology and Biostatistics, University of California , San Francisco, California , USA"},{"name":"Francis I. 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