{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:12:50Z","timestamp":1756897970959,"version":"3.37.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Independent Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Immunosuppressive agents may increase the risk of infections with human alphaherpesviruses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included all adult patients with moderate to severe psoriasis who initiated methotrexate (MTX) or biologic agents in a retrospective cohort study. An episode of alphaherpesviruses infection was defined as filling a prescription for systemic acyclovir, valacyclovir, or famciclovir. Using nationwide registries, we determined the incidence, risk factors, 180-day hospital contacts, and 30-day mortality following infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 7294 patients; 4978 (68%) received MTX, and 2316 (32%) biologic agents. The incidence rates (95% confidence intervals) of alphaherpesviruses were 23 (20\u201327), 26 (19\u201335), 17 (11\u201327), and 6.7 (1.3\u201321) per 1000 person-years of follow-up in patients on MTX, tumor necrosis factor alpha (TNF-\u03b1) inhibitors, interleukin 12\/23 (IL-12\/23) inhibitors, and interleukin 17 (IL-17) inhibitors, respectively. Males had an unadjusted hazard ratio (HR) of 0.47 (P &amp;lt; .001) for alphaherpesvirus infection. Patients on IL-17 inhibitors had an adjusted HR of 0.24 (P = .048) compared to TNF-\u03b1 inhibitors. Within 180 days after infection, 13%, 7.5%, and &amp;lt;0.5% of patients on MTX, TNF-\u03b1 inhibitors, and IL-12\/23 or IL-17 inhibitors, respectively, had hospital contacts, and the 30-day mortality for all groups was &amp;lt;0.5%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The incidence and risk of alphaherpesvirus infections were comparable between patients on MTX and TNF-\u03b1 inhibitors, whereas use of IL-17 inhibitors was associated with a lower risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiac367","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:52:40Z","timestamp":1662771160000},"page":"1510-1518","source":"Crossref","is-referenced-by-count":3,"title":["Incidence, Risk Factors, and Consequences of Human Alphaherpesvirus Infections in Patients With Psoriasis Who Initiate Methotrexate or Biologic Agents"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2198-1904","authenticated-orcid":false,"given":"Omid","family":"Rezahosseini","sequence":"first","affiliation":[{"name":"Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mie Sylow","family":"Liljendahl","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Dermatology, Bispebjerg Hospital , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolai","family":"Loft","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina Leth","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zitta Barrella","family":"Harboe","sequence":"additional","affiliation":[{"name":"Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Pulmonary and Infectious Diseases, Hospital of Nordsj\u00e6lland, Nordsj\u00e6llands University Hospital , Hiller\u00f8d , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads Kirchheiner","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"DERMBIO , Denmark"},{"name":"Department of Dermatology, Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kawa Khaled","family":"Ajgeiy","sequence":"additional","affiliation":[{"name":"DERMBIO , Denmark"},{"name":"Department of Dermatology, Odense University Hospital , Odense , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Egeberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital , Copenhagen , Denmark"},{"name":"DERMBIO , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen , Copenhagen , Denmark"},{"name":"DERMBIO , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne Dam","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Viro-immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"2022110117485328000_jiac367-B1","first-page":"1822","volume-title":"Mandell, Douglas, and Bennett's principles and practice of infectious diseases","author":"Cohen","year":"2020"},{"key":"2022110117485328000_jiac367-B2","first-page":"A4345","article-title":"Perceptions of herpes zoster and attitudes towards zoster vaccination among 50\u201365-year-old Danes","volume":"58","author":"Mortensen","year":"2011","journal-title":"Dan Med 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