{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:19:04Z","timestamp":1793053144165,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 AI135078"],"award-info":[{"award-number":["K08 AI135078"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AI142742"],"award-info":[{"award-number":["U19 AI142742"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bacteriophage therapy is the use of viruses to kill bacteria for the treatment of antibiotic-resistant infections. Little is known about the human immune response following phage therapy. We report the development of phage-specific CD4+ T cells alongside rising phage-specific immunoglobulin G and neutralizing antibodies in response to adjunctive bacteriophage therapy used to treat a multidrug-resistant Pseudomonas aeruginosa pneumonia in a lung transplant recipient. Clinically, treatment was considered a success despite the development phage-specific immune responses.<\/jats:p>","DOI":"10.1093\/infdis\/jiac368","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T16:54:46Z","timestamp":1662569686000},"page":"311-316","source":"Crossref","is-referenced-by-count":38,"title":["Development of Host Immune Response to Bacteriophage in a Lung Transplant Recipient on Adjunctive Phage Therapy for a Multidrug-Resistant Pneumonia"],"prefix":"10.1093","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-0657","authenticated-orcid":false,"given":"Jennifer M","family":"Dan","sequence":"first","affiliation":[{"name":"Center for Infectious Diseases and Vaccine Research, La Jolla Institute for Immunology , La Jolla, California , USA"},{"name":"Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California , San Diego, La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Lehman","sequence":"additional","affiliation":[{"name":"AmpliPhi Biosciences , San Diego, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Al-kolla","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases and Vaccine Research, La Jolla Institute for Immunology , La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Penziner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California , San Diego, La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamyar","family":"Afshar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California , San Diego, La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California , San Diego, La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Golts","sequence":"additional","affiliation":[{"name":"Department of Surgery. Division of Cardiovascular and Thoracic Surgery, University of California , San Diego, La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California , San Diego, La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Logan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California , San Diego, La Jolla, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Kovach","sequence":"additional","affiliation":[{"name":"AmpliPhi Australia , Sydney , 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