{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:46:00Z","timestamp":1792122360949,"version":"4.4.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000769","name":"University of Oxford","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Monitoring changes in pharyngeal carriage of pneumococcus in children following 13-valent pneumococcal conjugate vaccine (PCV13) introduction in the United Kingdom in 2010 informs understanding of patterns of invasive pneumococcal disease (IPD) incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nasopharyngeal swabs from healthy children vaccinated with PCV13 according to schedule (2, 4, and 12 months) were cultured and serotyped. Results for children aged 13\u201348 months were compared between 2014\u20132015 and 2017\u20132019 and with children aged 6\u201312 months (2017\u20132020). Blood was obtained from a subset of children for pneumococcal serotype-specific immunoglobulin G (IgG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total pneumococcal carriage at 13\u201348 months was 47.9% (473\/988) in 2014\u20132015 and 51.8% (412\/795) in 2017\u20132019 (P = .10); at age 6\u201312 months this value was 44.6% (274\/615). In 2017\u20132019, 2.9% (95% confidence interval, 1.8%\u20134.3%) of children aged 13\u201348 months carried PCV13 serotypes (mainly 3 [1.5%] and 19A [0.8%]) and &amp;gt;20% carried the additional 20-valent PCV (PCV20) serotypes. Similar proportions of children had IgG \u22650.35 IU\/mL for each serotype in 2014\u20132015 and 2017\u20132019. Serotype 7C carriage increased significantly (P &amp;lt; .01) between 2014\u20132015 and 2017\u20132019. Carriage of PCV20 serotypes 8 and 12F, both major causes of IPD, was rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Introduction of PCV20, if licensed for children, could significantly change the composition of pneumococcal serotypes carried in the pharynx of UK children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trials Registration<\/jats:title>\n                    <jats:p>NCT03102840.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiac376","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T16:42:25Z","timestamp":1663087345000},"page":"610-621","source":"Crossref","is-referenced-by-count":50,"title":["Nasopharyngeal Carriage of Pneumococcus in Children in England up to 10 Years After 13-Valent Pneumococcal Conjugate Vaccine Introduction: Persistence of Serotypes 3 and 19A and Emergence of 7C"],"prefix":"10.1093","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2125-4125","authenticated-orcid":false,"given":"Karen S","family":"Tiley","sequence":"first","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford , Oxford , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford , Oxford , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-6559","authenticated-orcid":false,"given":"Merryn","family":"Voysey","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford , Oxford , United 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