{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:08:49Z","timestamp":1793758129484,"version":"4.6.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001475","name":"Nanyang Technological University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001475","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac impairment contributes to hypotension in severe dengue (SD). However, studies examining pathogenic factors affecting dengue-associated cardiac impairment are lacking. We examined the role of neutrophil mediators on cardiac impairment in clinical dengue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled adult patients with dengue and controls. Cardiac parameters were measured using a bioimpedance device. Neutrophils mediators were measured, including myeloperoxidase (MPO) and citrullinated histone H3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We recruited 107 dengue patients and 30 controls. Patients with dengue were classified according to World Health Organization 2009 guidelines (44 with dengue fever [DF], 51 with DF with warning signs, and 12 with SD). During critical phase, stroke index (P &amp;lt; .001), cardiac index (P = .03), and Granov-Goor index (P &amp;lt; .001) were significantly lower in patients with dengue than in controls. During critical phase, MPO was significantly higher in patients with dengue than in controls (P &amp;lt; .001) and also significantly higher in patients with SD than in those with DF. In addition, MPO was inversely associated with the stroke, cardiac, and Granov-Goor indexes, during the critical phase, and longitudinally as well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cardiac function was decreased, and MPO increased, during with critical phase in patients SD compared with those with DF and controls. MPO may mediate dengue-associated cardiac impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiac383","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T13:24:02Z","timestamp":1663680242000},"page":"1974-1984","source":"Crossref","is-referenced-by-count":21,"title":["Association of Neutrophil Mediators With Dengue Disease Severity and Cardiac Impairment in Adults"],"prefix":"10.1093","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8797-9527","authenticated-orcid":false,"given":"Po Ying","family":"Chia","sequence":"first","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore"},{"name":"National Centre for Infectious Diseases , Singapore"},{"name":"Department of Infectious Diseases, Tan Tock Seng Hospital , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Teo","sequence":"additional","affiliation":[{"name":"Lee 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