{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:32:48Z","timestamp":1784842368259,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Dutch Organization for Health Research and Development","award":["10430072010008"],"award-info":[{"award-number":["10430072010008"]}]},{"name":"Health\u223cHolland","award":["EMCLHS20017"],"award-info":[{"award-number":["EMCLHS20017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The COVIH study is a prospective coronavirus disease 2019 (COVID-19) vaccination study in 1154 people with HIV (PWH), of whom 14% showed reduced antibody levels after primary vaccination. We evaluated whether an additional vaccination boosts immune responses in these hyporesponders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The primary end point was the increase in antibodies 28 days after additional mRNA-1273 vaccination. Secondary end points included neutralizing antibodies, S-specific T-cell and B-cell responses, and reactogenicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 66 participants, 40 previously received 2 doses ChAdOx1-S, 22 received 2 doses BNT162b2, and 4 received a single dose Ad26.COV2.S. The median age was 63 years (interquartile range [IQR], 60\u201366), 86% were male, and median CD4+ T-cell count was 650\/\u03bcL (IQR, 423\u2013941). The mean S1-specific antibody level increased from 35 binding antibody units (BAU)\/mL (95% confidence interval [CI], 24\u201346) to 4317 BAU\/mL (95% CI, 3275\u20135360) (P &amp;lt; .0001). Of all participants, 97% showed an adequate response and the 45 antibody-negative participants all seroconverted. A significant increase in the proportion of PWH with ancestral S-specific CD4+ T cells (P = .04) and S-specific B cells (P = .02) was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An additional mRNA-1273 vaccination induced a robust serological response in 97% of PWH with a hyporesponse after primary vaccination.<\/jats:p>\n                    <jats:p>Clinical Trials Registration. EUCTR2021-001054-57-N.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiac451","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T19:32:20Z","timestamp":1668627140000},"page":"651-662","source":"Crossref","is-referenced-by-count":17,"title":["Immunogenicity of an Additional mRNA-1273 SARS-CoV-2 Vaccination in People With HIV With Hyporesponse After Primary Vaccination"],"prefix":"10.1093","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-7281","authenticated-orcid":false,"given":"Marlou J","family":"Jongkees","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Section Infectious Diseases, and Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl","family":"Geers","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus University Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn S","family":"Hensley","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section Infectious Diseases, and Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5699-7087","authenticated-orcid":false,"given":"Wesley","family":"Huisman","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Leiden University Centre for Infectious Diseases, Leiden University Medical Centre , Leiden , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corine H","family":"GeurtsvanKessel","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus University Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Bogers","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus University Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennert","family":"Gommers","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus University Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigorios","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Erasmus University Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P","family":"Jochems","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Leiden University Centre for Infectious Diseases, Leiden University Medical Centre , Leiden , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G","family":"den Hollander","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Maasstad Hospital , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile F","family":"Schippers","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Leiden University Medical Centre , Leiden , the Netherlands"},{"name":"Department of Internal Medicine, Haga Teaching Hospital , the Hague , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi S M","family":"Ammerlaan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Catharina Hospital , Eindhoven , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter F W","family":"Bierman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, University Medical Centre Groningen , Groningen , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"van der Valk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, DC Klinieken , Amsterdam , the Netherlands"},{"name":"Department of Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centres , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin A H","family":"Berrevoets","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Elisabeth-Tweesteden Hospital , Tilburg , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Soetekouw","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, Spaarne Gasthuis , Haarlem , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke","family":"Langebeek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, Rijnstate Hospital , Arnhem , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke H W","family":"Bruns","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, University Medical Centre Utrecht , Utrecht , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane M S","family":"Leyten","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, Haaglanden Medical Centre , the Hague , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim C E","family":"Sigaloff","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centres , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit G A","family":"van Vonderen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical Centre Leeuwarden , Leeuwarden , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corine E","family":"Delsing","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, Medisch Spectrum Twente , Enschede , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Branger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Flevo Hospital , Almere , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D","family":"Katsikis","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus University Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus University Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory D","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus University Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart J A","family":"Rijnders","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section Infectious Diseases, and Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre , Rotterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees","family":"Brinkman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious 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