{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:11:28Z","timestamp":1780549888173,"version":"3.54.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U01 CK000107"],"award-info":[{"award-number":["U01 CK000107"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R43\/R44 AI096551"],"award-info":[{"award-number":["R43\/R44 AI096551"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dorothy Harrison Egan Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the Northeast and upper Midwest of the United States, Babesia microti and Borrelia burgdorferi use Ixodes scapularis ticks as vector and Peromyscus leucopus mice as major reservoir host. We previously established, in a 5-year field trial, that a reservoir-targeted outer surface protein A vaccine reduces the prevalence of B. burgdorferi-infected ticks. We accessed ticks and mouse blood samples collected during the trial, extracted total DNA, and amplified the B. microti 18S rRNA gene. Vaccine deployment reduced the prevalence of ticks coinfected with B. microti and that of mice infected with B. microti. Breaking the enzootic cycle of B. burgdorferi may reduce the incidence of babesiosis.<\/jats:p>","DOI":"10.1093\/infdis\/jiac462","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T08:29:55Z","timestamp":1669192195000},"page":"1127-1131","source":"Crossref","is-referenced-by-count":9,"title":["Deployment of a Reservoir-Targeted Vaccine Against <i>Borrelia burgdorferi<\/i> Reduces the Prevalence of <i>Babesia microti<\/i> Coinfection in <i>Ixodes scapularis<\/i> Ticks"],"prefix":"10.1093","volume":"227","author":[{"given":"Edouard","family":"Vannier","sequence":"first","affiliation":[{"name":"Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana M","family":"Richer","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center , Memphis, Tennessee , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duy M","family":"Dinh","sequence":"additional","affiliation":[{"name":"Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Brisson","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Pennsylvania , Philadelphia, Pennsylvania , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S","family":"Ostfeld","sequence":"additional","affiliation":[{"name":"Cary Institute of Ecosystem Studies , Millbrook, New York , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gomes-Solecki","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center , Memphis, Tennessee , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"2023051202561458900_jiac462-B1","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1056\/NEJMra1202018","article-title":"Human babesiosis","volume":"366","author":"Vannier","year":"2012","journal-title":"N Engl J Med"},{"key":"2023051202561458900_jiac462-B2","doi-asserted-by":"crossref","first-page":"ofaa608","DOI":"10.1093\/ofid\/ofaa608","article-title":"Babesiosis occurrence among United States Medicare beneficiaries, ages 65 and older, during 2006\u20132017: overall and by state and county of residence","volume":"8","author":"Menis","year":"2021","journal-title":"Open Forum Infect Dis"},{"key":"2023051202561458900_jiac462-B3","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.3201\/eid1812.111392","article-title":"Reservoir competence of wildlife host species for Babesia 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