{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:22:35Z","timestamp":1774502555626,"version":"3.50.1"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The recent mpox (monkeypox) outbreak has prompted genomic studies to track global spread of the disease. These studies have also revealed unexpected patterns of mutations that implicate the action of the immune defense APOBEC3 family of enzymes, which catalyze conversion of cytosine (C) to uracil (U) in DNA, in viral evolution. As poxviruses have conventionally been regarded as slow-evolving viruses, the rapid emergence of APOBEC3 mutational signatures begs a series of important and open questions regarding how host-pathogen interactions may have changed and whether these mutations are bystanders or have roles in pathogenesis.<\/jats:p>","DOI":"10.1093\/infdis\/jiac471","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T03:33:16Z","timestamp":1670556796000},"page":"828-830","source":"Crossref","is-referenced-by-count":3,"title":["Mpox Evolution: Has the Current Outbreak Revealed a Pox on \u201cU\u201d?"],"prefix":"10.1093","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7689-5678","authenticated-orcid":false,"given":"Rahul M","family":"Kohli","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia , Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart N","family":"Isaacs","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia , Pennsylvania , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"2023032810293867400_","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/s41591-022-01907-y","article-title":"Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus","volume":"28","author":"Isidro","year":"2022","journal-title":"Nat Med"},{"key":"2023032810293867400_","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.add4153","article-title":"Multiple lineages of monkeypox virus detected in the United States, 2021\u20132022","volume":"378","author":"Gigante","year":"2022","journal-title":"Science"},{"key":"2023032810293867400_","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a010199","article-title":"Poxvirus DNA replication","volume":"5","author":"Moss","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2023032810293867400_","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.virol.2015.03.012","article-title":"APOBECs and virus restriction","volume":"479","author":"Harris","year":"2015","journal-title":"Virology"},{"key":"2023032810293867400_","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1038\/s41588-022-01196-8","article-title":"Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer","volume":"54","author":"Petljak","year":"2022","journal-title":"Nat Genet"},{"key":"2023032810293867400_","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1743-422X-3-86","article-title":"Vaccinia virus replication is not affected by APOBEC3 family members","volume":"3","author":"Kremer","year":"2006","journal-title":"Virol J"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiac471\/48479712\/jiac471.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/227\/6\/828\/49675906\/jiac471.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/227\/6\/828\/49675906\/jiac471.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T07:25:04Z","timestamp":1701501904000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/227\/6\/828\/6884165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,9]]},"references-count":6,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,12,9]]},"published-print":{"date-parts":[[2023,3,28]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiac471","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,15]]},"published":{"date-parts":[[2022,12,9]]}}}