{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:05:14Z","timestamp":1740128714889,"version":"3.37.3"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["568971","1071269"],"award-info":[{"award-number":["568971","1071269"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001102","name":"Cancer Council New South Wales Strategic Research Partnership Program","doi-asserted-by":"publisher","award":["13-11"],"award-info":[{"award-number":["13-11"]}],"id":[{"id":"10.13039\/501100001102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000951","name":"Cancer Council Victoria","doi-asserted-by":"publisher","award":["1130507"],"award-info":[{"award-number":["1130507"]}],"id":[{"id":"10.13039\/501100000951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Gay and bisexual men (GBM) are at increased risk of human papillomavirus (HPV)\u2013associated anal high-grade squamous intraepithelial lesions (HSILs). Understanding the fractions of HSILs attributable to HPV genotypes is important to inform potential impacts of screening and vaccination strategies. However, multiple infections are common, making attribution of causative types difficult. Algorithms developed for predicting HSIL-causative genotype fractions have never been compared with a reference standard in GBM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Samples were from the Study of the Prevention of Anal Cancer. Baseline HPV genotypes detected in anal swab samples (160 participants) were compared with HPV genotypes in anal HSILs (222 lesions) determined by laser capture microdissection (LCM). Five algorithms were compared: proportional, hierarchical, maximum, minimum, and maximum likelihood estimation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All algorithms predicted HPV-16 as the most common HSIL-causative genotype, and proportions differed from LCM detection (37.8%) by algorithm (with differences of \u22126.1%, +20.9%, \u221220.4%, +2.9%, and +2.2% respectively). Fractions predicted using the proportional method showed a strong positive correlation with LCM, overall (R = 0.73 and P = .002), and by human immunodeficiency virus (HIV) status (HIV positive, R = 0.74 and P = .001; HIV-negative, R = 0.68 and P = .005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Algorithms produced a range of inaccurate estimates of HSIL attribution, with the proportional algorithm performing best. The high occurrence of multiple HPV infections means that these algorithms may be of limited use in GBM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiac503","type":"journal-article","created":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T14:33:25Z","timestamp":1672583605000},"page":"1407-1416","source":"Crossref","is-referenced-by-count":0,"title":["Performance of Human Papillomavirus Attribution Algorithms to Predict Causative Genotypes in Anal High-Grade Lesions"],"prefix":"10.1093","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-8111","authenticated-orcid":false,"given":"Samuel","family":"Phillips","sequence":"first","affiliation":[{"name":"Centre for Women's Infectious Diseases, The Royal Women's Hospital , Parkville, Victoria , Australia"},{"name":"Infection and Immunity, Murdoch Children's Research Institute , Parkville, Victoria , Australia"},{"name":"Department of Microbiology, University of the Sunshine Coast, Centre for Bioinnovation , Sippy Downs, Queensland , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa M","family":"Cornall","sequence":"additional","affiliation":[{"name":"Centre for Women's Infectious Diseases, The Royal Women's Hospital , Parkville, Victoria , Australia"},{"name":"Infection and Immunity, Murdoch Children's Research Institute , Parkville, Victoria , Australia"},{"name":"Department of Obstetrics and Gynecology, University of Melbourne , Parkville, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Molano","sequence":"additional","affiliation":[{"name":"Centre for Women's Infectious Diseases, The Royal Women's Hospital , Parkville, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyi","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of HIV Epidemiology and Prevention, The Kirby Institute, University of New South Wales , Kensington, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Histology, Douglass Hanly Moir Pathology , Macquarie Park, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabelle","family":"Farnsworth","sequence":"additional","affiliation":[{"name":"Department of Histology, Douglass Hanly Moir Pathology , Macquarie Park, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J","family":"Hillman","sequence":"additional","affiliation":[{"name":"The Western Sydney Sexual Health Centre, University of Sydney, Westmead Hospital , Westmead, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Templeton","sequence":"additional","affiliation":[{"name":"Department of HIV Epidemiology and Prevention, The Kirby Institute, University of New South Wales , Kensington, New South Wales , Australia"},{"name":"Department of Sexual Health Medicine, Sydney Local Health District , Camperdown, New South Wales , Australia"},{"name":"Discipline of Medicine, Central Clinical School, Faculty of Medicine and Health, The University of Sydney , Sydney, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I Mary","family":"Poynten","sequence":"additional","affiliation":[{"name":"Department of HIV Epidemiology and Prevention, The Kirby Institute, University of New South Wales , Kensington, New South Wales , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M","family":"Garland","sequence":"additional","affiliation":[{"name":"Centre for Women's Infectious Diseases, The Royal Women's Hospital , Parkville, Victoria , Australia"},{"name":"Infection and Immunity, Murdoch Children's Research Institute , Parkville, Victoria , Australia"},{"name":"Department of Obstetrics and Gynecology, University of Melbourne , Parkville, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher K","family":"Fairley","sequence":"additional","affiliation":[{"name":"Central Clinical School, Alfred Hospital, Monash University , Melbourne, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald L","family":"Murray","sequence":"additional","affiliation":[{"name":"Centre for Women's Infectious Diseases, The Royal Women's Hospital , Parkville, Victoria , Australia"},{"name":"Infection and Immunity, Murdoch Children's Research Institute , Parkville, Victoria , Australia"},{"name":"Department of Obstetrics and Gynecology, University of Melbourne , Parkville, Victoria , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepehr N","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Melbourne , 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