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We used a nonhuman primate model, which recapitulates human infection, to characterize the clinical, microbiologic, and radiographic patterns associated with developing latent M. tuberculosis infection. Four patterns were identified. \u201cControllers\u201d had normal erythrocyte sedimentation rate (ESR) without M. tuberculosis growth in bronchoalveolar lavage or gastric aspirate (BAL\/GA). \u201cEarly subclinicals\u201d showed transient ESR elevation and\/or M. tuberculosis growth on BAL\/GA for 60 days postinfection, \u201cmid subclinicals\u201d were positive for 90 days, and \u201clate subclinicals\u201d were positive intermittently, despite the absence of clinical disease. Variability was noted regarding granuloma formation, lung\/lymph node metabolic activity, lung\/lymph node bacterial burden, gross pathology, and extrapulmonary disease. Like human M. tuberculosis infection, this highlights the heterogeneity associated with the establishment of latent infection, underscoring the need to understand the clinical spectrum and risk factors associated with severe disease.<\/jats:p>","DOI":"10.1093\/infdis\/jiac504","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T04:15:41Z","timestamp":1673151341000},"page":"592-601","source":"Crossref","is-referenced-by-count":14,"title":["Characterizing the Spectrum of Latent<i>Mycobacterium tuberculosis<\/i>in the Cynomolgus Macaque Model: Clinical, Immunologic, and Imaging Features of Evolution"],"prefix":"10.1093","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4422-8416","authenticated-orcid":false,"given":"Jessica Marie","family":"Medrano","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Pittsburgh Medical Center's Children's Hospital of Pittsburgh, School of Medicine, University of Pittsburgh , 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