{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:49:34Z","timestamp":1769597374051,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011054","name":"Danida","doi-asserted-by":"publisher","award":["17-02-KU"],"award-info":[{"award-number":["17-02-KU"]}],"id":[{"id":"10.13039\/501100011054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["101028915"],"award-info":[{"award-number":["101028915"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Parasitemia among pregnant women with protective immunity to Plasmodium falciparum malaria is often dominated by VAR2CSA-positive infected erythrocytes (IEs). VAR2CSA mediates sequestration of IEs in the placenta. We hypothesized that the previously observed spontaneous postpartum clearance of parasitemia in such women is related to the expulsion of the placenta, which removes the sequestration focus of VAR2CSA-positive IEs. We assessed parasitemias and gene transcription before and shortly after delivery in 17 Ghanaian women. The precipitous decline in parasitemia postpartum was accompanied by selective reduction in transcription of the gene encoding VAR2CSA. Our findings provide a mechanistic explanation for the earlier observation.<\/jats:p>","DOI":"10.1093\/infdis\/jiad031","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T03:31:05Z","timestamp":1675654265000},"page":"196-201","source":"Crossref","is-referenced-by-count":3,"title":["The Rapid and Spontaneous Postpartum Clearance of <i>Plasmodium falciparum<\/i> Is Related to Expulsion of the Placenta"],"prefix":"10.1093","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1459-2559","authenticated-orcid":false,"given":"Nsoh G","family":"Anabire","sequence":"first","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana , Accra , Ghana"},{"name":"West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell, and Molecular Biology, University of Ghana , Accra , Ghana"},{"name":"Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-3324","authenticated-orcid":false,"given":"Maria del Pilar","family":"Quintana","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2341-7514","authenticated-orcid":false,"given":"Michael F","family":"Ofori","sequence":"additional","affiliation":[{"name":"Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana , Accra , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1698-4927","authenticated-orcid":false,"given":"Lars","family":"Hviid","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Infectious Diseases, Rigshospitalet , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"2023071405552668300_jiad031-B1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-immunol-032713-120220","article-title":"Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease","volume":"32","author":"Crompton","year":"2014","journal-title":"Annu Rev 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