{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:37:50Z","timestamp":1791995870157,"version":"4.4.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI150719"],"award-info":[{"award-number":["R01AI150719"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10OD011996-01"],"award-info":[{"award-number":["1S10OD011996-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Feitler Family"},{"name":"Max Goldenberg Foundation"},{"name":"Ann and Robert H. Lurie Children\u2019s Hospital of Chicago"},{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cancer Center Support","award":["NCI CA060553"],"award-info":[{"award-number":["NCI CA060553"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Kawasaki disease (KD) is a febrile illness of young childhood that can result in coronary artery aneurysms and death. Coronavirus disease 2019 (COVID-19) mitigation strategies resulted in a marked decrease in KD cases worldwide, supporting a transmissible respiratory agent as the cause. We previously reported a peptide epitope recognized by monoclonal antibodies (MAbs) derived from clonally expanded peripheral blood plasmablasts from 3 of 11 KD children, suggesting a common disease trigger in a subset of patients with KD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed amino acid substitution scans to develop modified peptides with improved recognition by KD MAbs. We prepared additional MAbs from KD peripheral blood plasmablasts and assessed MAb characteristics that were associated with binding to the modified peptides.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We report a modified peptide epitope that is recognized by 20 MAbs from 11 of 12 KD patients. These MAbs predominantly use heavy chain VH3-74; two-thirds of VH3-74 plasmablasts from these patients recognize the epitope. The MAbs were nonidentical between patients but share a common complementarity-determining region 3 (CDR3) motif.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These results demonstrate a convergent VH3-74 plasmablast response to a specific protein antigen in children with KD, supporting one predominant causative agent in the etiopathogenesis of the illness.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiad048","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T19:53:08Z","timestamp":1676749988000},"page":"412-421","source":"Crossref","is-referenced-by-count":13,"title":["Analysis of Plasmablasts From Children With Kawasaki Disease Reveals Evidence of a Convergent Antibody Response to a Specific Protein Epitope"],"prefix":"10.1093","volume":"228","author":[{"given":"Anne H","family":"Rowley","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA"},{"name":"Department of Microbiology\/Immunology, Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA"},{"name":"Ann and Robert H. Lurie Children's Hospital of Chicago , Chicago, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Arrollo","sequence":"additional","affiliation":[{"name":"Ann and Robert H. Lurie Children's Hospital of Chicago , Chicago, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanford T","family":"Shulman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA"},{"name":"Ann and Robert H. Lurie Children's Hospital of Chicago , Chicago, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Torres","sequence":"additional","affiliation":[{"name":"Ann and Robert H. Lurie Children's Hospital of Chicago , Chicago, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amornrat","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Loyola University Stritch School of Medicine , Maywood, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Wylie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Washington University in St Louis , St Louis, Missouri , USA"},{"name":"McDonnell Genome Institute, Washington University in St Louis , St Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Youn A","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Loyola University Stritch School of Medicine , Maywood, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"2023081611094145100_jiad048-B1","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"2023081611094145100_jiad048-B2","doi-asserted-by":"crossref","first-page":"e38998","DOI":"10.1371\/journal.pone.0038998","article-title":"Three linked vasculopathic processes characterize Kawasaki disease: a light and transmission electron microscopic study","volume":"7","author":"Orenstein","year":"2012","journal-title":"PLoS One"},{"key":"2023081611094145100_jiad048-B3","first-page":"681","article-title":"General pathology of Kawasaki disease. 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