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SNPs associated with CSF TNF concentrations were carried forward for analyses of pulmonary and meningeal tuberculosis susceptibility and TBM mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>MUC5AC SNP rs28737416 T allele was associated with lower CSF concentrations of TNF (P = 1.8 \u00d7 10\u22128) and IFN-\u03b3 (P = 2.3 \u00d7 10\u22126). In an additive genetic model, rs28737416 T\/T genotype was associated with higher susceptibility to TBM (odds ratio [OR], 1.24; 95% confidence interval [CI], 1.03\u20131.49; P = .02), but not pulmonary tuberculosis (OR, 1.11, 95% CI, .98\u20131.25; P = .10). TBM mortality was higher among participants with the rs28737416 T\/T and T\/C genotypes (35\/119, 30.4%) versus the C\/C genotype (11\/89, 12.4%; log-rank P = .005) in a Vietnam discovery cohort (n = 210), an independent Vietnam validation cohort (n = 87; 9\/87, 19.1% vs 1\/20, 2.5%; log-rank P = .02), and an Indonesia validation cohort (n = 468, 127\/287, 44.3% vs 65\/181, 35.9%; log-rank P = .06).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>MUC5AC variants may contribute to immune changes that influence TBM outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiad050","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T04:49:22Z","timestamp":1677214162000},"page":"343-352","source":"Crossref","is-referenced-by-count":10,"title":["<i>MUC5AC<\/i> Genetic Variation Is Associated With Tuberculous Meningitis Cerebral Spinal Fluid 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