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Recently, a highly potent Plasmodium falciparum transmission-blocking monoclonal antibody (TB31F) was demonstrated to be safe and efficacious in malaria-naive volunteers. Here we predict the potential public health impact of large-scale implementation of TB31F alongside existing interventions. We developed a pharmaco-epidemiological model, tailored to 2 settings of differing transmission intensity with already established insecticide-treated nets and seasonal malaria chemoprevention interventions. Community-wide annual administration (at 80% coverage) of TB31F over a 3-year period was predicted to reduce clinical incidence by 54% (381 cases averted per 1000 people per year) in a high-transmission seasonal setting, and 74% (157 cases averted per 1000 people per year) in a low-transmission seasonal setting. Targeting school-aged children gave the largest reduction in terms of cases averted per dose. An annual administration of the transmission-blocking monoclonal antibody TB31F may be an effective intervention against malaria in seasonal malaria settings.<\/jats:p>","DOI":"10.1093\/infdis\/jiad101","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T07:56:31Z","timestamp":1681286191000},"page":"212-223","source":"Crossref","is-referenced-by-count":10,"title":["Modeling the Impact of a Highly Potent\n                    <i>Plasmodium falciparum<\/i>\n                    Transmission-Blocking Monoclonal Antibody in Areas of Seasonal Malaria Transmission"],"prefix":"10.1093","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6029-1733","authenticated-orcid":false,"given":"Joseph D","family":"Challenger","sequence":"first","affiliation":[{"name":"Medical Research Council Centre for Global Infections Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London , London , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn W","family":"van Beek","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Radboud Institute for Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"ter Heine","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Radboud Institute for Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia C","family":"van der Boor","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Medical Center , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni D","family":"Charles","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Global Infections Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London , London , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merel J","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Medical Center , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Ockenhouse","sequence":"additional","affiliation":[{"name":"PATH Center for Vaccine Innovation and Access , Washington, District of Columbia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J","family":"Aponte","sequence":"additional","affiliation":[{"name":"PATH Center for Vaccine Innovation and Access , Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew B B","family":"McCall","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Medical Center , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthijs 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