{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:04:13Z","timestamp":1791644653630,"version":"4.3.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Ministry of Health, Welfare and Sport, the Netherlands"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Knowledge on genital type-specific human papillomavirus (HPV) prevalence among men is important for prevention of HPV-related cancers and other diseases. Men who have sex with men (MSM) have higher anal prevalence than men who have sex with women only (MSW) but for genital HPV this is unclear. We performed a systematic review and meta-analysis of type-specific genital HPV prevalence among men, by sexual orientation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>MEDLINE and Embase were used for searching publications reporting on male genital HPV prevalence with data from November 2011 onwards. A random-effects meta-analysis was conducted estimating pooled type-specific and grouped external genital and urethral HPV prevalence. Subgroup analyses were conducted for sexual orientation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-nine studies were eligible. Of those, 13 studies reported prevalence among MSM, 5 among MSW, and 13 studies did not stratify by sexual orientation. The most common genotypes were HPV-6 and HPV-16 for both anatomical locations, although heterogeneity was high. HPV prevalence was similar among studies reporting on MSW, MSM, and men with unknown sexual orientation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Genital HPV is common among men, with HPV-6 and HPV-16 being the most common genotypes. Type-specific HPV genital prevalence appears to be similar among MSM and MSW, which contrasts with earlier findings on anal HPV.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiad109","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T16:01:44Z","timestamp":1682006504000},"page":"1023-1032","source":"Crossref","is-referenced-by-count":10,"title":["Global Type-Specific Genital Human Papillomavirus Prevalence in Men, by Sexual Orientation: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"228","author":[{"given":"Johannes M A","family":"Kusters","sequence":"first","affiliation":[{"name":"Centre for Infectious Diseases Control, National Institute for Public Health and the Environment , Bilthoven , the Netherlands"},{"name":"Institute for Infection and Immunity, Amsterdam University Medical Centers , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesca G M","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases Control, National Institute for Public Health and the Environment , Bilthoven , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit H B","family":"van Benthem","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases Control, National Institute for Public Health and the Environment , Bilthoven , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke C M","family":"Heijne","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases Control, National Institute for Public Health and the Environment , Bilthoven , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten F","family":"Schim van der Loeff","sequence":"additional","affiliation":[{"name":"Institute for Infection and Immunity, Amsterdam University Medical Centers , Amsterdam , the Netherlands"},{"name":"Department of Infectious Diseases, Public Health Service of Amsterdam , Amsterdam , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"2023101809354454100_jiad109-B1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ijc.31027","article-title":"Immune evasion mechanisms of human papillomavirus: an update","volume":"142","author":"Steinbach","year":"2018","journal-title":"Int J Cancer"},{"key":"2023101809354454100_jiad109-B2","first-page":"80","article-title":"Review of HPV-related diseases and cancers","volume":"40","author":"Brianti","year":"2017","journal-title":"New Microbiol"},{"key":"2023101809354454100_jiad109-B3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers","year":"1999","journal-title":"J Pathol"},{"key":"2023101809354454100_jiad109-B4","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.ypmed.2011.08.002","article-title":"Genital HPV infection and related lesions in men","volume":"53","author":"Anic","year":"2011","journal-title":"Prev Med"},{"key":"2023101809354454100_jiad109-B5","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/ijc.30716","article-title":"Worldwide burden of cancer attributable to HPV by site, country and HPV type","volume":"141","author":"De Martel","year":"2017","journal-title":"Int J Cancer"},{"key":"2023101809354454100_jiad109-B6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1470-2045(18)30682-X","article-title":"Prevalence of human papillomavirus DNA and p16INK4a in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis","volume":"20","author":"Olesen","year":"2019","journal-title":"Lancet Oncol"},{"key":"2023101809354454100_jiad109-B7","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10552-008-9276-9","article-title":"Systematic review of human papillomavirus prevalence in invasive penile cancer","volume":"20","author":"Backes","year":"2009","journal-title":"Cancer Causes Control"},{"key":"2023101809354454100_jiad109-B8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4103\/aja.aja_39_19","article-title":"The relationship between human papillomavirus and penile cancer over the past decade: a systematic review and meta-analysis","volume":"21","author":"Yu","year":"2019","journal-title":"Asian J Androl"},{"key":"2023101809354454100_jiad109-B9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10552-017-0870-6","article-title":"Disease burden of human papillomavirus infection in the Netherlands, 1989\u20132014: the gap between females and males is diminishing","volume":"28","author":"McDonald","year":"2017","journal-title":"Cancer Causes Control"},{"key":"2023101809354454100_jiad109-B10","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.3390\/ijerph15102210","article-title":"Prevalence and risk factors of human papillomavirus in male patients: a systematic review and meta-analysis","volume":"15","author":"Rodr\u00edguez-\u00c1lvarez","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"2023101809354454100_jiad109-B11","doi-asserted-by":"crossref","first-page":"e40988","DOI":"10.1371\/journal.pone.0040988","article-title":"Prevalence of DNA-HPV in male sexual partners of HPV-infected women and concordance of viral types in infected couples","volume":"7","author":"Rocha","year":"2012","journal-title":"PLoS One"},{"key":"2023101809354454100_jiad109-B12","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1158\/1055-9965.EPI-10-0576","article-title":"Meta-analysis of human papillomavirus infection concordance","volume":"19","author":"Reiter","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2023101809354454100_jiad109-B13","first-page":"1","article-title":"Transmission of genital human papillomavirus infection in couples: a population-based cohort study in rural China","volume":"5","author":"Liu","year":"2015","journal-title":"Sci Rep"},{"key":"2023101809354454100_jiad109-B14","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/507432","article-title":"Prevalence of HPV infection among men: a systematic review of the literature","volume":"194","author":"Dunne","year":"2006","journal-title":"J Infect Dis"},{"key":"2023101809354454100_jiad109-B15","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jadohealth.2011.03.010","article-title":"Age-specific prevalence of human papillomavirus infection in males: a global review","volume":"48","author":"Smith","year":"2011","journal-title":"J Adolesc Health"},{"key":"2023101809354454100_jiad109-B16","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1111\/jsm.12652","article-title":"Prevalence of genital human papillomavirus among men in Europe: systematic review and meta-analysis","volume":"11","author":"Hebnes","year":"2014","journal-title":"J Sex Med"},{"key":"2023101809354454100_jiad109-B17","doi-asserted-by":"crossref","first-page":"e0229154","DOI":"10.1371\/journal.pone.0229154","article-title":"Prevalence of human papillomavirus (HPV) in Brazil: a systematic review and meta-analysis","volume":"15","author":"Colpani","year":"2020","journal-title":"PLoS One"},{"key":"2023101809354454100_jiad109-B18","doi-asserted-by":"crossref","first-page":"e2219","DOI":"10.1002\/rmv.2219","article-title":"Prevalence and genotype distribution of human papillomavirus infection in different anatomical sites among men who have sex with men: a systematic review and meta-analysis","volume":"31","author":"Farahmand","year":"2021","journal-title":"Rev Med Virol"},{"key":"2023101809354454100_jiad109-B19","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s10096-021-04229-y","article-title":"Human papillomavirus prevalence among men who have sex with men in China: a systematic review and meta-analysis","volume":"40","author":"Zhou","year":"2021","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2023101809354454100_jiad109-B20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(19)30298-3","article-title":"Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis","volume":"394","author":"Drolet","year":"2019","journal-title":"Lancet"},{"key":"2023101809354454100_jiad109-B21","doi-asserted-by":"crossref","first-page":"e0157976","DOI":"10.1371\/journal.pone.0157976","article-title":"Oral human papillomavirus infection in men who have sex with men: a systematic review and meta-analysis","volume":"11","author":"King","year":"2016","journal-title":"PLoS One"},{"key":"2023101809354454100_jiad109-B22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1470-2045(12)70080-3","article-title":"Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis","volume":"13","author":"Machalek","year":"2012","journal-title":"Lancet Oncol"},{"key":"2023101809354454100_jiad109-B23","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/infdis\/jiy556","article-title":"Type-specific anal human papillomavirus prevalence among men, according to sexual preference and HIV status: a systematic literature review and meta-analysis","volume":"219","author":"Marra","year":"2018","journal-title":"J Infect Dis"},{"key":"2023101809354454100_jiad109-B24","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/infdis\/jiy059","article-title":"Prevalence and risk factors for anal human papillomavirus infection in human immunodeficiency virus\u2013positive men who have sex with men","volume":"217","author":"Combes","year":"2018","journal-title":"J Infect Dis"},{"key":"2023101809354454100_jiad109-B25","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2023101809354454100_jiad109-B26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.15171\/ijhpm.2014.71","article-title":"The development of a critical appraisal tool for use in systematic reviews addressing questions of prevalence","volume":"3","author":"Munn","year":"2014","journal-title":"Int J Health Policy Manag"},{"key":"2023101809354454100_jiad109-B27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cct.2006.04.004","article-title":"Random-effects model for meta-analysis of clinical trials: an update","volume":"28","author":"DerSimonian","year":"2007","journal-title":"Contemp Clin Trials"},{"key":"2023101809354454100_jiad109-B28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1214\/aoms\/1177729756","article-title":"Transformations related to the angular and the square root","author":"Freeman","year":"1950","journal-title":"Ann Stat"},{"key":"2023101809354454100_jiad109-B29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/XEB.0000000000000054","article-title":"Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data","volume":"13","author":"Munn","year":"2015","journal-title":"Int J Evid Based Healthc"},{"key":"2023101809354454100_jiad109-B30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1037\/1082-989X.11.2.193","article-title":"Assessing heterogeneity in meta-analysis: Q statistic or I\u00b2 index?","volume":"11","author":"Huedo-Medina","year":"2006","journal-title":"Psychol Methods"},{"key":"2023101809354454100_jiad109-B31","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"2023101809354454100_jiad109-B32","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0895-4356(00)00242-0","article-title":"Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature","volume":"53","author":"Sterne","year":"2000","journal-title":"J Clin Epidemiol"},{"key":"2023101809354454100_jiad109-B33","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"2023101809354454100_jiad109-B34","volume-title":"Practical meta-analysis","author":"Lipsey","year":"2001"},{"key":"2023101809354454100_jiad109-B35","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1473-3099(07)70158-5","article-title":"Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis","volume":"7","author":"De Sanjos\u00e9","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"2023101809354454100_jiad109-B36","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1017\/S0950268817001698","article-title":"Genital HPV infection among heterosexual and homosexual male attendees of sexually transmitted diseases clinic in Beijing, China","volume":"145","author":"Xin","year":"2017","journal-title":"Epidemiol Infect"},{"key":"2023101809354454100_jiad109-B37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/infdis\/jiq021","article-title":"Age-specific prevalence of and risk factors for anal human papillomavirus (HPV) among men who have sex with women and men who have sex with men: the HPV in men (HIM) study","volume":"203","author":"Nyitray","year":"2011","journal-title":"J Infect Dis"},{"key":"2023101809354454100_jiad109-B38","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.vaccine.2006.05.031","article-title":"Epidemiology and transmission dynamics of genital HPV infection","volume":"24","author":"Burchell","year":"2006","journal-title":"Vaccine"},{"key":"2023101809354454100_jiad109-B39","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2022-055484","article-title":"Type-specific concurrent anogenital HPV detection among young women and MSM attending Dutch sexual health clinics","author":"Kusters","journal-title":"Sex Transm Infect"},{"key":"2023101809354454100_jiad109-B40","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1086\/591095","article-title":"Age-specific prevalence, incidence, and duration of human papillomavirus infections in a cohort of 290 US men","volume":"198","author":"Giuliano","year":"2008","journal-title":"J Infect Dis"},{"key":"2023101809354454100_jiad109-B41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/ijc.33185","article-title":"A meta-analysis of anal cancer incidence by risk group: toward a unified anal cancer risk scale","volume":"148","author":"Clifford","year":"2021","journal-title":"Int J Cancer"},{"key":"2023101809354454100_jiad109-B42","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1002\/ijc.29913","article-title":"Immunodeficiency and the risk of cervical intraepithelial neoplasia 2\/3 and cervical cancer: a nested case-control study in the Swiss HIV cohort study","volume":"138","author":"Clifford","year":"2016","journal-title":"Int J Cancer"},{"key":"2023101809354454100_jiad109-B43","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1002\/ijc.31989","article-title":"Assessment of herd effects among women and heterosexual men after girls-only HPV16\/18 vaccination in the Netherlands: a repeated cross-sectional study","volume":"144","author":"Woestenberg","year":"2019","journal-title":"Int J Cancer"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiad109\/50234147\/jiad109.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/228\/8\/1023\/52210052\/jiad109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/228\/8\/1023\/52210052\/jiad109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T09:37:31Z","timestamp":1697621851000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/228\/8\/1023\/7133617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,20]]},"references-count":43,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4,20]]},"published-print":{"date-parts":[[2023,10,18]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiad109","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,10,15]]},"published":{"date-parts":[[2023,4,20]]}}}