{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:39:55Z","timestamp":1788431995928,"version":"build-2803163510"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100012802","name":"Ragon Institute of MGH, MIT, and Harvard","doi-asserted-by":"publisher","award":["5R01Al151178-02"],"award-info":[{"award-number":["5R01Al151178-02"]}],"id":[{"id":"10.13039\/100012802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["5K08AI125682"],"award-info":[{"award-number":["5K08AI125682"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["5R03AI159780"],"award-info":[{"award-number":["5R03AI159780"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Studies have demonstrated the protective role of antibodies against malaria. Young children are known to be particularly vulnerable to malaria, pointing to the evolution of naturally acquired clinical immunity over time. However, whether changes in antibody functionality track with the acquisition of naturally acquired malaria immunity remains incompletely understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using systems serology, we characterized sporozoite- and merozoite-specific antibody profiles of uninfected Malian children before the malaria season who differed in their ability to control parasitemia and fever following Plasmodium falciparum (Pf) infection. We then assessed the contributions of individual traits to overall clinical outcomes, focusing on the immunodominant sporozoite CSP and merozoite AMA1 and MSP1 antigens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Humoral immunity evolved with age, with an expansion of both magnitude and functional quality, particularly within blood-stage phagocytic antibody activity. Moreover, concerning clinical outcomes postinfection, protected children had higher antibody-dependent neutrophil activity along with higher levels of MSP1-specific IgG3 and IgA and CSP-specific IgG3 and IgG4 prior to the malaria season.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These data point to the natural evolution of functional humoral immunity to Pf with age and highlight particular antibody Fc-effector profiles associated with the control of malaria in children, providing clues for the design of next-generation vaccines or therapeutics.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiad115","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T11:36:30Z","timestamp":1682508990000},"page":"759-768","source":"Crossref","is-referenced-by-count":13,"title":["Accumulation of Neutrophil Phagocytic Antibody Features Tracks With Naturally Acquired Immunity Against Malaria in Children"],"prefix":"10.1093","volume":"228","author":[{"given":"Nadege","family":"Nziza","sequence":"first","affiliation":[{"name":"Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University , Cambridge, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan M","family":"Tran","sequence":"additional","affiliation":[{"name":"Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, Maryland , USA"},{"name":"Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana , USA"},{"name":"Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine , Indianapolis, Indiana , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A","family":"DeRiso","sequence":"additional","affiliation":[{"name":"Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University , Cambridge, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Dolatshahi","sequence":"additional","affiliation":[{"name":"Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University , Cambridge, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Herman","sequence":"additional","affiliation":[{"name":"Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University , Cambridge, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"de Lacerda","sequence":"additional","affiliation":[{"name":"Program in Cellular and Molecular Medicine, Boston Children's Hospital , Boston, Massachusetts , USA"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, Massachusetts , USA"},{"name":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz , Belo Horizonte, MG , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Junqueira","sequence":"additional","affiliation":[{"name":"Program in Cellular and Molecular Medicine, Boston Children's Hospital , Boston, Massachusetts , USA"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, Massachusetts , USA"},{"name":"Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz , Belo Horizonte, MG , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Program in Cellular and Molecular Medicine, Boston Children's Hospital , Boston, Massachusetts , USA"},{"name":"Department of Pediatrics, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissata","family":"Ongoiba","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Centre, Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako , Bamako , Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safiatou","family":"Doumbo","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Centre, Mali International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako , Bamako , Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassoum","family":"Kayentao","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Centre, Mali International Center of Excellence in Research, University of Sciences, 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