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CMV infection and these proatherogenic T cells have been independently associated with cardiovascular disease and coronavirus disease 2019 (COVID-19) severity. We investigated the potential contribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to immunosenescence and its relationship with CMV. Innate and adaptive immune subpopulations from individuals with mild or asymptomatic SARS-CoV-2 infection (mCOVID-19) and healthy donors were immunophenotyped. A significant increase in CD28nullCD57+CX3CR1+ T cell percentages (CD4+ [P \u2264 .01], CD8+ [P \u2264 .01], and TcR\u03b3\u03b4 (CD4\u2212CD8\u2212) [P \u2264 .001]) was found in unnvaccinated CMV-seropositive mCOVID-19 individuals stable up to 12 months after infection. This expansion did not occur in CMV-seronegative mCOVID-19 individuals or in CMV-seropositive individuals infected after SARS-CoV-2 vaccination. There were no significant differences between mCOVID-19 and aortic stenosis groups. Thus, individuals coinfected with SARS-CoV-2 and CMV have accelerated T cell senescence, which might lead to an increased risk of cardiovascular disease.<\/jats:p>","DOI":"10.1093\/infdis\/jiad119","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T10:28:51Z","timestamp":1682591331000},"page":"576-585","source":"Crossref","is-referenced-by-count":23,"title":["Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection"],"prefix":"10.1093","volume":"228","author":[{"given":"Pablo","family":"\u00c1lvarez-Heredia","sequence":"first","affiliation":[{"name":"Immunology and Allergy Group (GC01), Maimonides Biomedical Research Institute of Cordoba (IMIBIC)\/University of Cordoba\/Reina Sofia University Hospital , C\u00f3rdoba , 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C\u00f3rdoba , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fakhri","family":"Hassouneh","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Group (GC01), Maimonides Biomedical Research Institute of Cordoba (IMIBIC)\/University of Cordoba\/Reina Sofia University Hospital , C\u00f3rdoba , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Batista-Duharte","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Group (GC01), Maimonides Biomedical Research Institute of Cordoba (IMIBIC)\/University of Cordoba\/Reina Sofia University Hospital , C\u00f3rdoba , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Bel\u00e9n","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Microbiology Service, Reina Sofia University Hospital of Cordoba\/Maimonides Biomedical Research Institute (IMIBIC)\/CIBERINFEC , C\u00f3rdoba , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Tarazona","sequence":"additional","affiliation":[{"name":"Department of Physiology, Immunology Unit, University of Extremadura , C\u00e1ceres , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Solana","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Group (GC01), Maimonides Biomedical Research Institute of Cordoba (IMIBIC)\/University of Cordoba\/Reina Sofia University Hospital , C\u00f3rdoba , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-8996","authenticated-orcid":false,"given":"Alejandra","family":"Pera","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Group (GC01), Maimonides Biomedical Research Institute of Cordoba (IMIBIC)\/University of Cordoba\/Reina Sofia University Hospital , C\u00f3rdoba , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"2023083107432421200_jiad119-B1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.37257","article-title":"Global percentage of asymptomatic SARS-CoV-2 infections among the tested population and individuals with confirmed COVID-19 diagnosis: a systematic review and meta-analysis","volume":"4","author":"Ma","year":"2021","journal-title":"JAMA Netw Open"},{"key":"2023083107432421200_jiad119-B2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/PHH.0000000000001331","article-title":"How many SARS-CoV-2-infected people require hospitalization? using random sample testing to better inform preparedness efforts","volume":"27","author":"Menachemi","year":"2021","journal-title":"J Public Health Manag 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