{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:54:26Z","timestamp":1790110466737,"version":"4.0.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dengue virus (DENV) is endemic in &amp;gt;100 countries, infecting an estimated 400 million individuals every year. Infection with DENV raises an antibody response primarily targeting viral structural proteins. However, DENV encodes several immunogenic nonstructural (NS) proteins, one of which, NS1, is expressed on the membrane of DENV-infected cells. IgG and IgA isotype antibodies that bind NS1 are abundant in serum following DENV infection. Our study aimed to determine if NS1-binding IgG and IgA isotype antibodies contribute to the clearance of DENV-infected cells by antibody-mediated cellular phagocytosis. We observed that both IgG and IgA isotype antibodies can facilitate monocytic uptake of DENV NS1-expressing cells in an Fc\u03b3RI- and Fc\u03b1RI-dependent fashion. Interestingly, this process was antagonized by the presence of soluble NS1, suggesting that the production of soluble NS1 by infected cells may serve as immunological chaff, antagonizing opsonization and clearance of DENV-infected cells.<\/jats:p>","DOI":"10.1093\/infdis\/jiad122","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T21:00:21Z","timestamp":1682542821000},"page":"70-79","source":"Crossref","is-referenced-by-count":12,"title":["Soluble NS1 Antagonizes IgG- and IgA- Mediated Monocytic Phagocytosis of DENV Infected Cells"],"prefix":"10.1093","volume":"228","author":[{"given":"Mitchell J","family":"Waldran","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, State University of New York Upstate Medical University , Syracuse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam D","family":"Wegman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, State University of New York Upstate Medical University , Syracuse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E","family":"Bahr","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, State University of New York Upstate Medical University , Syracuse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan H","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, State University of New York Upstate Medical University , Syracuse"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R","family":"Currier","sequence":"additional","affiliation":[{"name":"Viral Diseases Branch, Walter Reed Army Institute of Research , Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam T","family":"Waickman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, State University of New York Upstate Medical University , Syracuse"},{"name":"Institute for Global Health and Translational Sciences, State University of New York Upstate Medical University , Syracuse"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"2023062813220223600_jiad122-B1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"2023062813220223600_jiad122-B2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4269\/ajtmh.2011.10-0503","article-title":"Economic impact of dengue illness in the Americas","volume":"84","author":"Shepard","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"2023062813220223600_jiad122-B3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.4269\/ajtmh.1989.40.571","article-title":"Aedes aegypti and Aedes aegypti\u2013borne disease control in the 1990s: top down or bottom up. 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