{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T21:00:07Z","timestamp":1788642007980,"version":"build-2803163510"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"Supplement_6","license":[{"start":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T00:00:00Z","timestamp":1697328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01 AI40758"],"award-info":[{"award-number":["5R01 AI40758"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01 AI051517"],"award-info":[{"award-number":["1R01 AI051517"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016302","name":"Coalition for Epidemic Preparedness Innovations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016302","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henry Hillman Family Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Paramyxoviridae family includes established human pathogens such as measles virus, mumps virus, and the human parainfluenza viruses; highly lethal zoonotic pathogens such as Nipah virus; and a number of recently identified agents, such as Sosuga virus, which remain poorly understood. The high human-to-human transmission rate of paramyxoviruses such as measles virus, high case fatality rate associated with other family members such as Nipah virus, and the existence of poorly characterized zoonotic pathogens raise concern that known and unknown paramyxoviruses have significant pandemic potential. In this review, the general life cycle, taxonomic relationships, and viral pathogenesis are described for paramyxoviruses that cause both systemic and respiratory system\u2013restricted infections. Next, key gaps in critical areas are presented, following detailed conversations with subject matter experts and based on the current literature. Finally, we present an assessment of potential prototype pathogen candidates that could be used as models to study this important virus family, including assessment of the strengths and weaknesses of each potential prototype.<\/jats:p>","DOI":"10.1093\/infdis\/jiad123","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:18:26Z","timestamp":1697609906000},"page":"S390-S397","source":"Crossref","is-referenced-by-count":42,"title":["Paramyxoviruses: Pathogenesis, Vaccines, Antivirals, and Prototypes for Pandemic Preparedness"],"prefix":"10.1093","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1716-6376","authenticated-orcid":false,"given":"W Paul","family":"Duprex","sequence":"first","affiliation":[{"name":"Center for Vaccine Research"},{"name":"Department of Microbiology and Molecular Genetics, University of Pittsburgh , Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca Ellis","family":"Dutch","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine , Lexington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"2024041205151976900_jiad123-B1","first-page":"504","volume-title":"Fields virology","author":"Plemper","year":"2021","edition":"7th ed"},{"key":"2024041205151976900_jiad123-B2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.20506\/rst.36.2.2676","article-title":"Rinderpest eradication: challenges for remaining disease free and implications for future eradication efforts","volume":"36","author":"Hamilton","year":"2017","journal-title":"Rev Sci Tech"},{"key":"2024041205151976900_jiad123-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.aivir.2016.12.001","article-title":"Zoonotic potential of emerging paramyxoviruses: knowns and 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