{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:55:12Z","timestamp":1787856912803,"version":"build-2784847793"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871655"],"award-info":[{"award-number":["81871655"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970886"],"award-info":[{"award-number":["31970886"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Natural Science Foundation","doi-asserted-by":"publisher","award":["2022B1515020050"],"award-info":[{"award-number":["2022B1515020050"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Scientific Research Foundation of Guangdong Province, China","award":["B2019220"],"award-info":[{"award-number":["B2019220"]}]},{"DOI":"10.13039\/100012540","name":"Guangdong Innovative and Entrepreneurial Research Team Program","doi-asserted-by":"publisher","award":["2014ZT05S123"],"award-info":[{"award-number":["2014ZT05S123"]}],"id":[{"id":"10.13039\/100012540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The impact of hepatitis B surface antigen (HBsAg)\u2013negative\/hepatitis B virus (HBV) DNA\u2013positive occult HBV infection (OBI) on the severity of liver fibrosis remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 1772 patients negative for HBsAg but positive for antibody to hepatitis B core antigen (HBcAg), stratified by the presence or absence of OBI, were selected for long-term carriage leading to elevation of \u22652 of 4 liver fibrosis indexes\u2014hyaluronic acid (HA), laminin, type III procollagen peptide (PCIII), and type IV collagen (CIV)\u2014at testing in a Chinese hospital. Patients were tested for serum viral load, HBV markers, and histopathological changes in liver biopsy specimens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>OBI was identified in 148 patients with liver fibrosis (8.4%), who had significantly higher levels of HA, laminin, PCIII, and CIV than 1624 fibrotic patients without OBI (P &amp;lt; .05). In 36 patients with OBI who underwent liver biopsy, significant correlations were observed between OBI viral load and serum HA levels (P = .01), PCIII levels (P = .01), and pathological histological activity index (HAI) scores (P &amp;lt; .001), respectively; HAI scores and PCIII levels (P = .04); HBcAg immunohistochemical scores and HA levels (P &amp;lt; .001); and HBcAg immunohistochemical scores and PCIII levels (P = .03). Positive fluorescent in situ hybridization results were significantly more frequent in patients with OBIs (80.6% vs 37.5% in those without OBIs). Among patients with OBIs, HBcAg was detected in the liver tissue in 52.8% and HBsAg in 5.6%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>OBI status appears to be associated with liver fibrosis severity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiad140","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T10:55:46Z","timestamp":1683888946000},"page":"1375-1384","source":"Crossref","is-referenced-by-count":16,"title":["Occult Hepatitis B Virus Infection and Liver Fibrosis in Chinese Patients"],"prefix":"10.1093","volume":"228","author":[{"given":"Xi","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University , Guangzhou , China"},{"name":"Department of Infectious Diseases, The First Foshan People's Hospital , Foshan 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Candotti","sequence":"additional","affiliation":[{"name":"Department of Virology, Henri Mondor Hospital, AP-HP and University of Paris-Est, INSERM U955, IMRB , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Allain","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University , Guangzhou , China"},{"name":"Depratment of Haematology, University of Cambridge , Cambridge , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University , Guangzhou , 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