{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:39:35Z","timestamp":1791819575154,"version":"4.3.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010474","name":"SHCS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010474","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["177499"],"award-info":[{"award-number":["177499"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SHCS Research Foundation"},{"name":"5 Swiss university hospitals"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Bone mineral density (BMD) loss may be accelerated in people with HIV (PLWH). It is unknown whether a polygenic risk score (PRS) is associated with low BMD in PLWH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Swiss HIV Cohort Study participants of self-reported European descent underwent \u22652 per-protocol dual x-ray absorptiometry (DXA) measurements \u22652 years apart (2011\u20132020). Univariable and multivariable odds ratios (ORs) for DXA-defined osteoporosis were based on traditional and HIV-related risk factors and a genome-wide PRS built from 9413 single-nucleotide polymorphisms associated with low BMD in the general population. Controls were free from osteoporosis\/osteopenia on all DXA measurements.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 438 participants: 149 with osteoporosis and 289 controls (median age, 53 years; 82% male, 95% with suppressed HIV RNA). Participants with unfavorable osteoporosis PRS (top vs bottom quintile) had univariable and multivariable-adjusted osteoporosis ORs of 4.76 (95% CI, 2.34\u20139.67) and 4.13 (1.86\u20139.18), respectively. For comparison, hepatitis C seropositivity, 5-year tenofovir disoproxil fumarate exposure, and parent history of hip fracture yielded univariable osteoporosis ORs of 2.26 (1.37\u20133.74), 1.84 (1.40\u20132.43), and 1.54 (0.82\u20132.9).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In PLWH in Switzerland, osteoporosis was independently associated with a BMD-associated PRS after adjustment for established risk factors, including exposure to tenofovir disoproxil fumarate.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiad179","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T02:23:10Z","timestamp":1684981390000},"page":"742-750","source":"Crossref","is-referenced-by-count":8,"title":["Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV: The Swiss HIV Cohort Study"],"prefix":"10.1093","volume":"228","author":[{"given":"Johannes M","family":"Schwenke","sequence":"first","affiliation":[{"name":"University Department of Medicine and Infectious Diseases Service, Kantonsspital Baselland, University of Basel, Bruderholz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian W","family":"Thorball","sequence":"additional","affiliation":[{"name":"Precision Medicine Unit, Lausanne University Hospital, University of Lausanne"},{"name":"School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella C","family":"Schoepf","sequence":"additional","affiliation":[{"name":"University Department of Medicine and Infectious Diseases Service, Kantonsspital Baselland, University of Basel, Bruderholz"},{"name":"Department of Infectious Diseases, Bern University Hospital, University of Bern , 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