{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:26:58Z","timestamp":1791581218091,"version":"4.3.4"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020955","name":"GlaxoSmithKline Biologicals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Developing a vaccine to prevent congenital cytomegalovirus (CMV) infection and newborn disability requires an understanding of infection incidence. In a prospective cohort study of 363 adolescent girls (NCT01691820), CMV serostatus, primary infection, and secondary infection were determined in blood and urine samples collected at enrollment and every 4 months for 3 years. Baseline CMV seroprevalence was 58%. Primary infection occurred in 14.8% of seronegative girls. Among seropositive girls, 5.9% had \u22654-fold increase in anti-CMV antibody, and 23.9% shed CMV DNA in urine. Our findings provide insights on infection epidemiology and highlight the need for more standardized markers of secondary infection.<\/jats:p>","DOI":"10.1093\/infdis\/jiad182","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T05:57:46Z","timestamp":1687327066000},"page":"1491-1495","source":"Crossref","is-referenced-by-count":9,"title":["Incidence of Cytomegalovirus Primary and Secondary Infection in Adolescent Girls: Results From a Prospective Study"],"prefix":"10.1093","volume":"228","author":[{"given":"Robert","family":"Paris","sequence":"first","affiliation":[{"name":"Vaccines, GSK, Rockville , Maryland, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Apter","sequence":"additional","affiliation":[{"name":"VL-Medi Clinical Research Center , Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Boppana","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Microbiology, University of Alabama at Birmingham , Birmingham, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"D\u2019Aloia","sequence":"additional","affiliation":[{"name":"Vaccines, GSK , Rixensart, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"De Schrevel","sequence":"additional","affiliation":[{"name":"Vaccines, GSK , Rixensart, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Delroisse","sequence":"additional","affiliation":[{"name":"Vaccines, GSK , Wavre , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Grassano","sequence":"additional","affiliation":[{"name":"Vaccines, GSK , Siena , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Guignard","sequence":"additional","affiliation":[{"name":"Vaccines, GSK , Wavre , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil A","family":"Panackal","sequence":"additional","affiliation":[{"name":"Vaccines, GSK, Rockville , Maryland, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Roman","sequence":"additional","affiliation":[{"name":"Vaccines, GSK , Wavre , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Vaccines, GSK, Rockville , Maryland, US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa M","family":"Yunes","sequence":"additional","affiliation":[{"name":"Center for Research on Population Health, National Institute of Public Health , Cuernavaca , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Dieussaert","sequence":"additional","affiliation":[{"name":"Vaccines, GSK , Wavre , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"2023112802473634600_jiad182-B1","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1542\/peds.2014-1173","article-title":"Hearing loss and congenital CMV infection: a systematic review","volume":"134","author":"Goderis","year":"2014","journal-title":"Pediatrics"},{"key":"2023112802473634600_jiad182-B2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/rmv.535","article-title":"Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection","volume":"17","author":"Kenneson","year":"2007","journal-title":"Rev Med Virol"},{"key":"2023112802473634600_jiad182-B3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jcv.2017.09.006","article-title":"Outcomes of congenital cytomegalovirus disease following maternal primary and non-primary infection","volume":"96","author":"Giannattasio","year":"2017","journal-title":"J Clin Virol"},{"key":"2023112802473634600_jiad182-B4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3109\/14767058.2016.1169521","article-title":"Cytomegalovirus non-primary infection during pregnancy. 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