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In this study, we categorized ACTIV-2\/A5401 participants based on the extent of immunocompromise into none, mild, moderate, and severe immunocompromise. Moderate\/severe immunocompromise was associated with higher nasal viral load at enrollment (adjusted difference in means: 0.47 95% confidence interval, .12\u2013.83 log10 copies\/mL) and showed a trend toward higher cumulative nasal RNA levels and plasma viremia compared to nonimmunocompromised individuals. Immunosuppression leads to greater viral shedding and altered severe acute respiratory syndrome coronavirus 2 viral decay kinetics.<\/jats:p>\n                  <jats:p>Clinical Trials Registration.\u2003NCT04518410.<\/jats:p>","DOI":"10.1093\/infdis\/jiad200","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:28:31Z","timestamp":1685579311000},"page":"S111-S116","source":"Crossref","is-referenced-by-count":14,"title":["Immune Status and SARS-CoV-2 Viral Dynamics"],"prefix":"10.1093","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-0571","authenticated-orcid":false,"given":"Yijia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Pittsburgh , Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5601-9112","authenticated-orcid":false,"given":"Carlee","family":"Moser","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T. 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