{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:42:03Z","timestamp":1791895323860,"version":"4.3.4"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"Supplement_7","funder":[{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ebola virus (EBOV) causes lethal disease in ferrets, whereas Marburg virus (MARV) does not. To investigate this difference, we first evaluated viral entry by infecting ferret spleen cells with vesicular stomatitis viruses pseudotyped with either MARV or EBOV glycoprotein (GP). Both viruses were capable of infecting ferret spleen cells, suggesting that lack of disease is not due to a block in MARV entry. Next, we evaluated replication kinetics of authentic MARV and EBOV in ferret cell lines and demonstrated that, unlike EBOV, MARV was only capable of low levels of replication. Finally, we inoculated ferrets with a recombinant EBOV expressing MARV GP in place of EBOV GP. Infection resulted in uniformly lethal disease within 7\u20139 days postinfection, while MARV-inoculated animals survived until study endpoint. Together these data suggest that the inability of MARV to cause disease in ferrets is not entirely linked to GP.<\/jats:p>","DOI":"10.1093\/infdis\/jiad206","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T07:54:18Z","timestamp":1686210858000},"page":"S594-S603","source":"Crossref","is-referenced-by-count":8,"title":["The Inability of Marburg Virus to Cause Disease in Ferrets Is Not Solely Linked to the Virus Glycoprotein"],"prefix":"10.1093","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4778-4941","authenticated-orcid":false,"given":"Zachary","family":"Schiffman","sequence":"first","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada , Winnipeg, Manitoba , Canada"},{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg, Manitoba , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Garnett","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada , Winnipeg, Manitoba , Canada"},{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg, Manitoba , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylie N","family":"Tran","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada , Winnipeg, Manitoba , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguang","family":"Cao","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada , Winnipeg, Manitoba , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"He","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada , Winnipeg, Manitoba , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Emeterio","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada , Winnipeg, Manitoba , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Tierney","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada , Winnipeg, Manitoba , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Azaransky","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology 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