{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:53:08Z","timestamp":1792446788859,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"Supplement_7","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000016","name":"Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI142785"],"award-info":[{"award-number":["U19AI142785"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UC7AI094660"],"award-info":[{"award-number":["UC7AI094660"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007865","name":"University of Texas Medical Branch","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The filovirus Bundibugyo virus (BDBV) causes severe disease with a mortality rate of approximately 20%\u201351%. The only licensed filovirus vaccine in the United States, Ervebo, consists of a recombinant vesicular stomatitis virus (rVSV) vector that expresses Ebola virus (EBOV) glycoprotein (GP). Ervebo was shown to rapidly protect against fatal Ebola disease in clinical trials; however, the vaccine is only indicated against EBOV. Recent outbreaks of other filoviruses underscore the need for additional vaccine candidates, particularly for BDBV infections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>To examine whether the rVSV vaccine candidate rVSV\u0394G\/BDBV-GP could provide therapeutic protection against BDBV, we inoculated seven cynomolgus macaques with 1000 plaque-forming units of BDBV, administering rVSV\u0394G\/BDBV-GP vaccine to 6 of them 20\u201323 minutes after infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Five of the treated animals survived infection (83%) compared to an expected natural survival rate of 21% in this macaque model. All treated animals showed an early circulating immune response, while the untreated animal did not. Surviving animals showed evidence of both GP-specific IgM and IgG production, while animals that succumbed did not produce significant IgG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This small, proof-of-concept study demonstrated early treatment with rVSV\u0394G\/BDBV-GP provides a survival benefit in this nonhuman primate model of BDBV infection, perhaps through earlier initiation of adaptive immunity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiad207","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T20:08:48Z","timestamp":1686254928000},"page":"S712-S720","source":"Crossref","is-referenced-by-count":30,"title":["A Recombinant Vesicular Stomatitis Virus\u2013Based Vaccine Provides Postexposure Protection Against Bundibugyo Ebolavirus Infection"],"prefix":"10.1093","volume":"228","author":[{"given":"Courtney","family":"Woolsey","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas , USA"},{"name":"Galveston National Laboratory, University of Texas Medical Branch , Galveston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Strampe","sequence":"additional","affiliation":[{"name":"National Emerging Infectious Diseases Laboratories, Boston University , Boston, Massachusetts , USA"},{"name":"Department of Microbiology, Boston University School of Medicine , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla A","family":"Fenton","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas , USA"},{"name":"Galveston National Laboratory, University of Texas Medical Branch , Galveston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystle N","family":"Agans","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas , USA"},{"name":"Galveston National Laboratory, University of Texas Medical Branch , Galveston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas , USA"},{"name":"Galveston National Laboratory, University of Texas Medical Branch , Galveston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriya","family":"Borisevich","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas , USA"},{"name":"Galveston National Laboratory, University of Texas Medical Branch , Galveston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie S","family":"Dobias","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas , USA"},{"name":"Galveston National Laboratory, University of Texas Medical Branch , Galveston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Deer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas , USA"},{"name":"Galveston National Laboratory, University of Texas Medical Branch , Galveston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan B","family":"Geisbert","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas , USA"},{"name":"Galveston National Laboratory, University of Texas Medical Branch , Galveston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W","family":"Cross","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas , USA"},{"name":"Galveston National Laboratory, University of Texas Medical Branch , Galveston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8867-7256","authenticated-orcid":false,"given":"John H","family":"Connor","sequence":"additional","affiliation":[{"name":"National Emerging Infectious Diseases Laboratories, Boston University , Boston, Massachusetts , USA"},{"name":"Department of Microbiology, Boston University School of Medicine , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-1877","authenticated-orcid":false,"given":"Thomas W","family":"Geisbert","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, Texas , USA"},{"name":"Galveston National Laboratory, University of Texas Medical Branch , Galveston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"2023111521050803000_jiad207-B1","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJMra1901594","article-title":"Ebola","volume":"382","author":"Feldmann","year":"2020","journal-title":"N Engl J Med"},{"key":"2023111521050803000_jiad207-B2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-020-0147-3","article-title":"Ebola virus 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