{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:21:22Z","timestamp":1792794082097,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Rigshospitalet Research Council"},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health and Care Research Manchester Biomedical Research Center","id":[{"id":"https:\/\/ror.org\/0187kwz08","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People with human immunodeficiency virus (PWH) have an increased risk of chronic lung diseases and chronic inflammation. We aimed to investigate if inflammatory markers and monocyte activation are associated with faster lung function decline in PWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 655 PWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study. Eligible participants were aged \u226525 years and had 2 spirometries separated by &amp;gt;2 years. Inflammatory markers (interleukin [IL]\u20131\u03b2, IL-2, IL-6, IL-10, tumor necrosis factor\u2013\u03b1, and interferon-\u03b3) were measured at baseline by Luminex, and soluble CD14 and soluble CD163 by enzyme-linked immunosorbent assay. Using linear mixed models, we investigated whether elevated cytokine levels were associated with faster lung function decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The majority of PWH were males (85.2%) with undetectable viral replication (95.3%). We found a faster decline in forced expiratory volume in 1 second (FEV1) in PWH with elevated IL-1\u03b2 and IL-10, with an additional decline of 10.3 mL\/year (95% confidence interval [CI], 2.1\u201318.6; P = .014) and 10.0 mL\/year (95% CI, 1.8\u201318.2; P = .017), respectively. We found no interaction between smoking and IL-1\u03b2 or IL-10 on FEV1 decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated IL-1\u03b2 and IL-10 were independently associated with faster lung function decline in PWH, suggesting that dysregulated systemic inflammation may play a role in the pathogenesis of chronic lung diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiad233","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T08:22:18Z","timestamp":1687854138000},"page":"1080-1088","source":"Crossref","is-referenced-by-count":10,"title":["Elevated Levels of Interleukin-1\u03b2 and Interleukin-10 Are Associated With Faster Lung Function Decline in People With Well-Treated Human Immunodeficiency Virus"],"prefix":"10.1093","volume":"228","author":[{"given":"Rebekka F","family":"Thudium","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Rigshospitalet, University of Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-863X","authenticated-orcid":false,"given":"Nicoline S","family":"Arentoft","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Rigshospitalet, University of Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedda","family":"Hoel","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1442-4694","authenticated-orcid":false,"given":"Shoaib","family":"Afzal","sequence":"additional","affiliation":[{"name":"The Copenhagen General Population Study, Department of Clinical Biochemistry, Copenhagen University Hospital\u2014Herlev and Gentofte , Herlev"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob H","family":"von Stemann","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-0869","authenticated-orcid":false,"given":"Julie L","family":"Forman","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section of Biostatistics, University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon T","family":"Wilcke","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Herlev-Gentofte Hospital , Gentofte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0698-9385","authenticated-orcid":false,"given":"Thomas","family":"Benfield","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences"},{"name":"Department of Infectious Diseases, Copenhagen University Hospital\u2014Amager and Hvidovre Hospital , Hvidovre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Tr\u00f8seid","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet , Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro H","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Immunology, Statens Serum Institut , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisse R","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences"},{"name":"Department of Clinical Immunology, Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Vestbo","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine, University of Manchester , Manchester , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken M","family":"Kunisaki","sequence":"additional","affiliation":[{"name":"Minneapolis Veterans Affairs Health Care System , Minneapolis, Minnesota, USA"},{"name":"Department of Medicine, University of Minnesota , Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Ulrik 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