{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:05:48Z","timestamp":1792785948006,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alfred Health"},{"DOI":"10.13039\/501100001782","name":"the University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"E. P. F. C."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bacterial vaginosis (BV) is a common vaginal dysbiosis that often recurs following first-line antibiotics. We investigated if vaginal microbiota composition was associated with BV recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed samples and data from 121 women who participated in 3 published trials evaluating novel interventions for improving BV cure, including concurrent antibiotic treatment of regular sexual partners (RSPs). Women diagnosed with BV received first-line antibiotics and self-collected vaginal swabs pretreatment and the day after finishing antibiotics (immediately posttreatment). 16S rRNA gene sequencing was performed on vaginal samples. Logistic regression explored associations between BV recurrence and features of the vaginal microbiota pre- and posttreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen women (13% [95% confidence interval {CI}, 8%\u201321%]) experienced BV recurrence within 1 month of treatment. Women with an untreated RSP were more likely to experience recurrence than women with no RSP (P = .008) or an RSP who received treatment (P = .011). A higher abundance of Prevotella pretreatment (adjusted odds ratio [AOR], 1.35 [95% CI, 1.05\u20131.91]) and Gardnerella immediately posttreatment (AOR, 1.23 [95% CI, 1.03\u20131.49]) were associated with increased odds of BV recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Having specific Prevotella spp prior to recommended treatment and persistence of Gardnerella immediately posttreatment may contribute to the high rates of BV recurrence. Interventions that target these taxa are likely required to achieve sustained BV cure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/infdis\/jiad261","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T09:20:30Z","timestamp":1688721630000},"page":"646-656","source":"Crossref","is-referenced-by-count":22,"title":["<i>Prevotella<\/i>\n                    and\n                    <i>Gardnerella<\/i>\n                    Are Associated With Treatment Failure Following First-line Antibiotics for Bacterial Vaginosis"],"prefix":"10.1093","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5710-2671","authenticated-orcid":false,"given":"Erica L","family":"Plummer","sequence":"first","affiliation":[{"name":"Central Clinical School, Monash University, Melbourne, Victoria, Australia"},{"name":"Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia M","family":"Sfameni","sequence":"additional","affiliation":[{"name":"Central Clinical School, Monash University, Melbourne, Victoria, Australia"},{"name":"Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka A","family":"Vodstrcil","sequence":"additional","affiliation":[{"name":"Central Clinical School, Monash University, Melbourne, Victoria, Australia"},{"name":"Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia"},{"name":"Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Danielewski","sequence":"additional","affiliation":[{"name":"Molecular Microbiology, Murdoch Children's Research Institute, Parkville, Victoria, Australia"},{"name":"Women's Centre for Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia"},{"name":"Department of Obstetrics and Gynaecology, University of Melbourne , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald L","family":"Murray","sequence":"additional","affiliation":[{"name":"Molecular Microbiology, Murdoch Children's Research Institute, Parkville, Victoria, Australia"},{"name":"Women's Centre for Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia"},{"name":"Department of Obstetrics and Gynaecology, University of Melbourne , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda","family":"Fehler","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K","family":"Fairley","sequence":"additional","affiliation":[{"name":"Central Clinical School, Monash University, Melbourne, Victoria, Australia"},{"name":"Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M","family":"Garland","sequence":"additional","affiliation":[{"name":"Molecular Microbiology, Murdoch Children's Research Institute, Parkville, Victoria, Australia"},{"name":"Women's Centre for Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia"},{"name":"Department of Obstetrics and Gynaecology, University of Melbourne , Parkville, Victoria , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric P F","family":"Chow","sequence":"additional","affiliation":[{"name":"Central Clinical School, Monash University, Melbourne, Victoria, Australia"},{"name":"Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia"},{"name":"Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane S","family":"Hocking","sequence":"additional","affiliation":[{"name":"Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona S","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Central Clinical School, Monash University, Melbourne, Victoria, Australia"},{"name":"Melbourne Sexual Health Centre, Alfred Hospital, Carlton, Victoria, Australia"},{"name":"Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, 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