{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:58:43Z","timestamp":1791932323655,"version":"4.3.4"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"Supplement_7","funder":[{"DOI":"10.13039\/100017540","name":"Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vesicular stomatitis virus\u2013Ebola virus (VSV-EBOV) vaccine has been successfully used in ring vaccination approaches during EBOV disease outbreaks demonstrating its general benefit in short-term prophylactic vaccination, but actual proof of its benefit in true postexposure prophylaxis (PEP) for humans is missing. Animal studies have indicated PEP efficacy when VSV-EBOV was used within hours of lethal EBOV challenge. Here, we used a lower EBOV challenge dose and a combined intravenous and intramuscular VSV-EBOV administration to improve PEP efficacy in the rhesus macaque model. VSV-EBOV treatment 1 hour after EBOV challenge resulted in delayed disease progression but little benefit in outcome. Thus, we could not confirm previous results indicating questionable benefit of VSV-EBOV for EBOV PEP in a nonhuman primate model.<\/jats:p>","DOI":"10.1093\/infdis\/jiad280","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T23:46:19Z","timestamp":1689810379000},"page":"S721-S729","source":"Crossref","is-referenced-by-count":10,"title":["Limited Benefit of Postexposure Prophylaxis With VSV-EBOV in Ebola Virus\u2013Infected Rhesus Macaques"],"prefix":"10.1093","volume":"228","author":[{"given":"Trenton","family":"Bushmaker","sequence":"first","affiliation":[{"name":"Laboratory of Virology, Rocky Mountain Laboratories, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Feldmann","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Lovaglio","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Saturday","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J","family":"Griffin","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Rocky Mountain Laboratories, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle L","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Rocky Mountain Laboratories, National Institutes of Health , Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E","family":"Strong","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada , Winnipeg, Manitoba , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Sprecher","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res , Brussels , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Kobinger","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch at Galveston , Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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