{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:12:20Z","timestamp":1791843140895,"version":"4.3.4"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IRCCS Sacro Cuore Don Calabria"},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Italy"},{"DOI":"10.13039\/100014013","name":"UKRI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004815","name":"Isaac Newton Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004815","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>While symbiotic relationships between invertebrates and bacteria have been extensively described, studies of microbial communities inhabiting parasitic worms remain scarce. Exploring the microbiota associated with helminths responsible for major infectious diseases will inform on parasite biology, host-pathogen interactions, and disease pathophysiology. We investigated the presence of microorganisms inhabiting tissues of the human parasite Schistosoma mansoni. In situ hybridization using a pan-bacterial 16S rRNA gene probe revealed bacteria colonizing key developmental stages that were successfully removed after antibiotic treatment of live parasites. Understanding the composition and function of the S. mansoni-associated microbiota may lead to the development of novel microbiome-targeting control strategies<\/jats:p>","DOI":"10.1093\/infdis\/jiad288","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T23:02:41Z","timestamp":1690239761000},"page":"1299-1303","source":"Crossref","is-referenced-by-count":14,"title":["The Human Blood Fluke, <i>Schistosoma mansoni<\/i>, Harbors Bacteria Throughout the Parasite's Life Cycle"],"prefix":"10.1093","volume":"228","author":[{"given":"Fabio","family":"Formenti","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge , Cambridge , United Kingdom"},{"name":"IRCCS Sacro Cuore Don Calabria Hospital , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge , Cambridge , United Kingdom"},{"name":"Departament de Farm\u00e0cia, Tecnologia Farmac\u00e8utica I Parasitologia, Facultat de Farm\u00e0cia, Universitat de Val\u00e8ncia , Burjassot , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Deiana","sequence":"additional","affiliation":[{"name":"IRCCS Sacro Cuore Don Calabria Hospital , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah","family":"Salter","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge , Cambridge , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Parkhill","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge , Cambridge , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Berriman","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute , Hinxton , United Kingdom"},{"name":"Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow , Glasgow , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute , Hinxton , United Kingdom"},{"name":"Department of Life Sciences, Aberystwyth University , Aberystwyth , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-2950","authenticated-orcid":false,"given":"Cinzia","family":"Cantacessi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge , Cambridge , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"2023110719192716300_jiad288-B1","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1016\/S1473-3099(16)30475-3","article-title":"Human schistosomiasis in the post mass drug administration era","volume":"17","author":"Mutapi","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"2023110719192716300_jiad288-B2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pt.2018.10.007","article-title":"Helminth microbiomes\u2014a hidden treasure trove?","volume":"35","author":"Jenkins","year":"2019","journal-title":"Trends Parasitol"},{"key":"2023110719192716300_jiad288-B3","doi-asserted-by":"crossref","first-page":"e0263188","DOI":"10.1371\/journal.pone.0263188","article-title":"Adult schistosomes have an epithelial bacterial population distinct from the surrounding mammalian host blood","volume":"17","author":"Gobert","year":"2022","journal-title":"PLoS One"},{"key":"2023110719192716300_jiad288-B4","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1017\/S0031182009991211","article-title":"Culture for genetic manipulation of developmental stages of Schistosoma mansoni","volume":"137","author":"Mann","year":"2010","journal-title":"Parasitology"},{"key":"2023110719192716300_jiad288-B5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/cyto.990140205","article-title":"Optimizing fluorescent in situ hybridization with rRNA-targeted oligonucleotide probes for flow cytometric identification of microorganisms","volume":"14","author":"Wallner","year":"1993","journal-title":"Cytometry"},{"key":"2023110719192716300_jiad288-B6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00427-009-0285-9","article-title":"The embryonic development of Schistosoma mansoni eggs: proposal for a new staging system","volume":"219","author":"Jurberg","year":"2009","journal-title":"Dev Genes Evol"},{"key":"2023110719192716300_jiad288-B7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0022-2011(80)90040-3","article-title":"The fine structure of the miracidium of Schistosoma mansoni","volume":"36","author":"Pan","year":"1980","journal-title":"J Invertebr Pathol"},{"key":"2023110719192716300_jiad288-B8","doi-asserted-by":"crossref","first-page":"624178","DOI":"10.3389\/fimmu.2020.624178","article-title":"Immune evasion strategies of schistosomes","volume":"11","author":"Hambrook","year":"2021","journal-title":"Front Immunol"},{"key":"2023110719192716300_jiad288-B9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0014-4894(71)90084-1","article-title":"Schistosoma mansoni: fine structure of cercarial acetabular glands","volume":"30","author":"Dorsey","year":"1971","journal-title":"Exp Parasitol"},{"key":"2023110719192716300_jiad288-B10","doi-asserted-by":"crossref","first-page":"e1006537","DOI":"10.1371\/journal.pgen.1006537","article-title":"Genomes of Fasciola hepatica from the Americas reveal colonization with Neorickettsia endobacteria related to the agents of Potomac horse and human Sennetsu fevers","volume":"13","author":"McNulty","year":"2017","journal-title":"PLoS Genet"},{"key":"2023110719192716300_jiad288-B11","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3181\/00379727-130-33706","article-title":"Schistosoma mansoni eggs: an electron microscopic study of shell pores and microbarbs","volume":"130","author":"Race","year":"1969","journal-title":"Proc Soc Exp Biol Med"},{"key":"2023110719192716300_jiad288-B12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/infdis\/141.2.177","article-title":"Parasite-parasite interaction of Salmonella typhimurium and Schistosoma","volume":"141","author":"LoVerde","year":"1980","journal-title":"J Infect Dis"},{"key":"2023110719192716300_jiad288-B13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0035-9203(73)90006-0","article-title":"Interaction of salmonellae and schistosomes in host-parasite relations","volume":"67","author":"Young","year":"1973","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2023110719192716300_jiad288-B14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1128\/iai.44.2.274-281.1984","article-title":"Mechanism of interaction of Salmonella and Schistosoma species","volume":"44","author":"Melhem","year":"1984","journal-title":"Infect Immun"},{"key":"2023110719192716300_jiad288-B15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0035-9203(72)90056-9","article-title":"Studies on the effects of bacteria on experimental schistosome infections in animals","volume":"66","author":"Ottens","year":"1972","journal-title":"Trans R Soc Trop Med Hyg"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiad288\/51099868\/jiad288.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/228\/9\/1299\/52789689\/jiad288.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/228\/9\/1299\/52789689\/jiad288.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T19:38:21Z","timestamp":1699385901000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/228\/9\/1299\/7230260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,24]]},"references-count":15,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,7,24]]},"published-print":{"date-parts":[[2023,11,2]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiad288","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11,1]]},"published":{"date-parts":[[2023,7,24]]}}}