{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:19:18Z","timestamp":1780373958444,"version":"3.54.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Research of Korea Agencies for Disease Control and Prevention","award":["20220313E05-0"],"award-info":[{"award-number":["20220313E05-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Our study aimed to determine the risk of herpes zoster reactivation and coronavirus disease 2019 (COVID-19) vaccination (mRNA vaccine [BNT162b2] and adenovirus-vectored vaccine [ChAdOx1 nCoV-19]).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective study analyzed herpes zoster cases diagnosed between 26 February 2021 and 30 June 2021 and registered in the National Health Insurance Service database. A matched case-control study with a 1:3 matching ratio and a propensity score matching (PSM) study with a 1:1 ratio of vaccinated and unvaccinated individuals were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the matched case control analysis, BNT162b2 was associated with an increased risk of herpes zoster reactivation (first dose adjusted odds ratio [aOR], 1.11; 95% confidence interval [CI], 1.06\u20131.15; second dose aOR, 1.17; 95% CI, 1.12\u20131.23). PSM analysis revealed a statistically significant increase in risk within 18 days following any vaccination (adjusted hazard ratio [aHR], 1.09; 95% CI, 1.02\u20131.16). BNT162b2 was associated with an increased risk at 18 days postvaccination (aHR, 1.65; 95% CI, 1.35\u20132.02) and second dose (aHR, 1.10; 95% CI, 1.02\u20131.19). However, the risk did not increase in both analyses of ChAdOx1 vaccination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>mRNA COVID-19 vaccination possibly increases the risk of herpes zoster reactivation, and thus close follow-up for herpes zoster reactivation is required.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiad297","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T12:02:23Z","timestamp":1691409743000},"page":"1326-1335","source":"Crossref","is-referenced-by-count":6,"title":["Herpes Zoster Reactivation After mRNA and Adenovirus-Vectored Coronavirus Disease 2019 Vaccination: Analysis of National Health Insurance Database"],"prefix":"10.1093","volume":"228","author":[{"given":"Jin Gu","family":"Yoon","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Guro Hospital, Korea University College of Medicine , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Big Data Department, National Health Insurance Service , Wonju , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Joo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, International St Mary's Hospital, Catholic Kwandong University College of Medicine , Incheon , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Suk","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Ansan Hospital, Korea University College of Medicine , Ansan , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Bin","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehun","family":"Jung","sequence":"additional","affiliation":[{"name":"Artificial Intelligence and Big-Data Convergence Center, Gachon University College of Medicine , Incheon , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak-Jun","family":"Hyun","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Guro Hospital, Korea University College of Medicine , Seoul , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye","family":"Seong","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Guro Hospital, Korea University College of Medicine , Seoul , South 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