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ARE-BPs are known to fine-tune RNA turnover and translational activity. We identified putative AREs within EBOV mRNA 3\u2032 UTRs and assessed whether they might modulate mRNA stability. Using mammalian and zebrafish embryo reporter assays, we show a conserved, ARE-BP-mediated stabilizing effect and increased reporter activity with the tested EBOV 3\u2032 UTRs. When coexpressed with the prototypic ARE-BP tristetraprolin (TTP, ZFP36) that mainly destabilizes its target mRNAs, the EBOV nucleoprotein (NP) 3\u2032 UTR resulted in decreased reporter gene activity. Coexpression of NP with TTP led to reduced NP protein expression and diminished EBOV minigenome activity. In conclusion, the enrichment of AU residues in EBOV 3\u2032 UTRs makes them possible targets for cellular ARE-BPs, leading to modulation of RNA stability and translational activity.<\/jats:p>","DOI":"10.1093\/infdis\/jiad312","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T07:41:20Z","timestamp":1691480480000},"page":"S488-S497","source":"Crossref","is-referenced-by-count":7,"title":["The 3\u2032 Untranslated Regions of Ebola Virus mRNAs Contain AU-Rich Elements Involved in Posttranscriptional Stabilization and Decay"],"prefix":"10.1093","volume":"228","author":[{"given":"Emily V","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Virology, Immunology, and Microbiology, Chobanian and Avedisian School of Medicine, Boston University , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Virology, 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Biochemistry and Cell Biology, Chobanian and Avedisian School of Medicine, Boston University , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn M","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell Biology, Chobanian and Avedisian School of Medicine, Boston University , Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Cifuentes","sequence":"additional","affiliation":[{"name":"Department of Virology, Immunology, and Microbiology, Chobanian and Avedisian School of Medicine, Boston University , Boston, Massachusetts , USA"},{"name":"Department of Biochemistry and Cell Biology, Chobanian and Avedisian School of Medicine, Boston University , Boston, Massachusetts , 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