{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:45:09Z","timestamp":1790851509418,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"Supplement_7","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI106772"],"award-info":[{"award-number":["U19AI106772"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ebola virus (EBOV) is a highly pathogenic virus that encodes 7 multifunctional structural proteins. Multiple host factors have been reported to interact with the EBOV proteins. Here, we found that tripartite motif-containing 14 (TRIM14), an interferon-stimulated gene that mediates cellular signaling pathways associated with type I interferon and inflammatory cytokine production, interacts with EBOV nucleoprotein to enhance interferon-\u03b2 (IFN-\u03b2) and nuclear factor-\u03baB (NF-\u03baB) promotor activation. Moreover, TRIM14 overexpression reduced viral replication in an infectious but biologically contained EBOV\u0394VP30 system by approximately 10-fold without affecting viral protein expression. Furthermore, TRM14-deficient mice were more susceptible to mouse-adapted EBOV infection than wild-type mice. Our data suggest that TRIM14 is a host factor with anti-EBOV activity that limits EBOV pathogenesis.<\/jats:p>","DOI":"10.1093\/infdis\/jiad325","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T20:46:54Z","timestamp":1691614014000},"page":"S514-S521","source":"Crossref","is-referenced-by-count":13,"title":["An Antiviral Role for TRIM14 in Ebola Virus Infection"],"prefix":"10.1093","volume":"228","author":[{"given":"Makoto","family":"Kuroda","sequence":"first","affiliation":[{"name":"Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison , Madison, Wisconsin , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Halfmann","sequence":"additional","affiliation":[{"name":"Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison , Madison, Wisconsin , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa B","family":"Thackray","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine , St Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Diamond","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine , St Louis, Missouri , USA"},{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St Louis, Missouri , USA"},{"name":"Department of Molecular Microbiology, Washington University School of Medicine , St Louis, Missouri , USA"},{"name":"The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine , St Louis, Missouri , USA"},{"name":"Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine , St Louis, Missouri , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9448-8227","authenticated-orcid":false,"given":"Heinz","family":"Feldmann","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, Montana , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-9587","authenticated-orcid":false,"given":"Andrea","family":"Marzi","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Hamilton, Montana , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kawaoka","sequence":"additional","affiliation":[{"name":"Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison , Madison, Wisconsin , USA"},{"name":"Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo , Tokyo , Japan"},{"name":"The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute , Tokyo , Japan"},{"name":"Pandemic Preparedness, Infection and Advanced Research Center, University of Tokyo , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"2023111521060083900_jiad325-B1","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2016.0297","article-title":"The Ebola outbreak, 2013\u20132016: old lessons for new epidemics","volume":"372:","author":"Coltart","year":"2017","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2023111521060083900_jiad325-B2","author":"World Health Organization (WHO)"},{"key":"2023111521060083900_jiad325-B3","author":"World Health Organization (WHO)"},{"key":"2023111521060083900_jiad325-B4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41423-020-00602-7","article-title":"Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors","volume":"18","author":"Onomoto","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"2023111521060083900_jiad325-B5","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1016\/j.bbamcr.2014.08.004","article-title":"The intricate interplay between RNA viruses and NF-kappaB","volume":"1843","author":"Schmitz","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"2023111521060083900_jiad325-B6","first-page":"662","article-title":"Host and viral modulation of RIG-I-mediated antiviral immunity","volume":"7","author":"Liu","year":"2016","journal-title":"Front Immunol"},{"key":"2023111521060083900_jiad325-B7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrmicro3524","article-title":"Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus","volume":"13","author":"Messaoudi","year":"2015","journal-title":"Nat Rev Microbiol"},{"key":"2023111521060083900_jiad325-B8","doi-asserted-by":"crossref","first-page":"5168","DOI":"10.1128\/JVI.02199-05","article-title":"Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha\/beta interferon production induced by RIG-I signaling","volume":"80","author":"Cardenas","year":"2006","journal-title":"J Virol"},{"key":"2023111521060083900_jiad325-B9","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.chom.2013.06.010","article-title":"Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome","volume":"14","author":"Luthra","year":"2013","journal-title":"Cell Host Microbe"},{"key":"2023111521060083900_jiad325-B10","doi-asserted-by":"crossref","first-page":"12500","DOI":"10.1128\/JVI.02163-14","article-title":"Molecular basis for ebolavirus VP35 suppression of human dendritic cell maturation","volume":"88","author":"Yen","year":"2014","journal-title":"J Virol"},{"key":"2023111521060083900_jiad325-B11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1099\/vir.0.017343-0","article-title":"The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide","volume":"91","author":"Jin","year":"2010","journal-title":"J Gen Virol"},{"key":"2023111521060083900_jiad325-B12","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1128\/JVI.02349-05","article-title":"Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation","volume":"80","author":"Reid","year":"2006","journal-title":"J Virol"},{"key":"2023111521060083900_jiad325-B13","doi-asserted-by":"crossref","first-page":"13469","DOI":"10.1128\/JVI.01097-07","article-title":"Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1","volume":"81","author":"Reid","year":"2007","journal-title":"J Virol"},{"key":"2023111521060083900_jiad325-B14","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1128\/JVI.01372-09","article-title":"Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling","volume":"84","author":"Mateo","year":"2010","journal-title":"J Virol"},{"key":"2023111521060083900_jiad325-B15","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1038\/s41467-020-16768-7","article-title":"Identification of interferon-stimulated genes that attenuate Ebola virus infection","volume":"11","author":"Kuroda","year":"2020","journal-title":"Nat Commun"},{"key":"2023111521060083900_jiad325-B16","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nri2413","article-title":"TRIM Family proteins and their emerging roles in innate immunity","volume":"8","author":"Ozato","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"2023111521060083900_jiad325-B17","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nature12862","article-title":"Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity","volume":"505","author":"Schoggins","year":"2014","journal-title":"Nature"},{"key":"2023111521060083900_jiad325-B18","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.3389\/fimmu.2018.01872","article-title":"Identification of TRIM14 as a type I IFN-stimulated gene controlling hepatitis B virus replication by targeting HBx","volume":"9","author":"Tan","year":"2018","journal-title":"Front Immunol"},{"key":"2023111521060083900_jiad325-B19","doi-asserted-by":"crossref","first-page":"32336","DOI":"10.1038\/srep32336","article-title":"TRIM14 Inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"key":"2023111521060083900_jiad325-B20","doi-asserted-by":"crossref","first-page":"E245","DOI":"10.1073\/pnas.1316941111","article-title":"TRIM14 Is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response","volume":"111","author":"Zhou","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023111521060083900_jiad325-B21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/path.4456","article-title":"Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses","volume":"235","author":"Martines","year":"2015","journal-title":"J Pathol"},{"key":"2023111521060083900_jiad325-B22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-pathol-052016-100506","article-title":"The pathogenesis of Ebola virus disease","volume":"12","author":"Baseler","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"2023111521060083900_jiad325-B23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.molcel.2017.09.035","article-title":"Assembly of the WHIP-TRIM14-PPP6C mitochondrial complex promotes RIG-I-mediated antiviral signaling","volume":"68","author":"Tan","year":"2017","journal-title":"Mol Cell"},{"key":"2023111521060083900_jiad325-B24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.molcel.2016.08.025","article-title":"TRIM14 Inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses","volume":"64","author":"Chen","year":"2016","journal-title":"Mol Cell"},{"key":"2023111521060083900_jiad325-B25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41435-021-00128-6","article-title":"Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways","volume":"22","author":"Nenasheva","year":"2021","journal-title":"Genes Immun"},{"key":"2023111521060083900_jiad325-B26","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3389\/fmicb.2019.00344","article-title":"Inhibition of influenza A virus replication by TRIM14 via its multifaceted protein-protein interaction with NP","volume":"10","author":"Wu","year":"2019","journal-title":"Front Microbiol"},{"key":"2023111521060083900_jiad325-B27","article-title":"TRIM14 Promotes noncanonical NF-kappaB activation by modulating p100\/p52 stability via selective autophagy","volume":"7","author":"Chen","year":"2020","journal-title":"Adv Sci (Weinh)"},{"key":"2023111521060083900_jiad325-B28","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1073\/pnas.0708057105","article-title":"Generation of biologically contained Ebola viruses","volume":"105","author":"Halfmann","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023111521060083900_jiad325-B29","doi-asserted-by":"crossref","first-page":"S453","DOI":"10.1093\/infdis\/jiy208","article-title":"Ebola virus infection in commonly used laboratory mouse strains","volume":"218","author":"Haddock","year":"2018","journal-title":"J Infect Dis"},{"key":"2023111521060083900_jiad325-B30","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1128\/JVI.80.8.3743-3751.2006","article-title":"Functional mapping of the nucleoprotein of Ebola virus","volume":"80","author":"Watanabe","year":"2006","journal-title":"J Virol"},{"key":"2023111521060083900_jiad325-B31","doi-asserted-by":"publisher","DOI":"10.1101\/2021.05.14.444205","article-title":"Common mechanism of SARS-CoV and SARS-CoV-2 pathogenesis across species","author":"Schafer","year":"2021","journal-title":"bioRxiv"},{"key":"2023111521060083900_jiad325-B32","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.celrep.2018.04.027","article-title":"Recently identified mutations in the Ebola virus\u2013Makona genome do not alter pathogenicity in animal models","volume":"23","author":"Marzi","year":"2018","journal-title":"Cell Rep"},{"key":"2023111521060083900_jiad325-B33","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41586-018-0630-0","article-title":"Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex at 3.6 A resolution","volume":"563","author":"Sugita","year":"2018","journal-title":"Nature"},{"key":"2023111521060083900_jiad325-B34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010616","article-title":"Assembly and transport of filovirus nucleocapsids","volume":"18","author":"Dolnik","year":"2022","journal-title":"PLoS Pathog"},{"key":"2023111521060083900_jiad325-B35","doi-asserted-by":"crossref","first-page":"e02100","DOI":"10.1128\/JVI.02100-19","article-title":"Ebola virus inclusion body formation and RNA synthesis are controlled by a novel domain of nucleoprotein interacting with VP35","volume":"94:","author":"Miyake","year":"2020","journal-title":"J Virol"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiad325\/51091565\/jiad325.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/228\/Supplement_7\/S514\/53451823\/jiad325.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/228\/Supplement_7\/S514\/53451823\/jiad325.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T21:13:49Z","timestamp":1700082829000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/228\/Supplement_7\/S514\/7240712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,10]]},"references-count":35,"journal-issue":{"issue":"Supplement_7","published-online":{"date-parts":[[2023,8,10]]},"published-print":{"date-parts":[[2023,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiad325","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11,15]]},"published":{"date-parts":[[2023,8,10]]}}}