{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:15:39Z","timestamp":1780362939468,"version":"3.54.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171753"],"award-info":[{"award-number":["82171753"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971473"],"award-info":[{"award-number":["81971473"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000211"],"award-info":[{"award-number":["82000211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Calcitonin gene-related peptide (CGRP), an immunomodulatory neuropeptide, is important for regulating pain transmission, vasodilation, and the inflammatory response. However, the molecular mechanisms of the CGRP-mediated immune response remain unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The effects of CGRP on bacterial meningitis (BM) and its underlying mechanisms were investigated in BM mice in vivo and macrophages in vitro.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Peripheral injection of CGRP attenuated cytokine storms and protected mice from fatal pneumococcal meningitis, marked by increased bacterial clearance, improved neuroethology, and reduced mortality. When the underlying mechanisms were investigated, we found that CGRP induces proteasome-dependent degradation of major histocompatibility complex class II (MHC-II) in macrophages and then inhibits CD4+ T-cell activation. MARCH1 was identified as an E3 ligase that can be induced by CGRP engagement and promote K48-linked ubiquitination and degradation of MHC-II in macrophages. These results provide new insights into neuropeptide CGRP-mediated immune regulation mechanisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We conclude that targeting the nervous system and manipulating neuroimmune communication is a promising strategy for treating intracranial infections like BM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiad358","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T16:38:11Z","timestamp":1692635891000},"page":"855-865","source":"Crossref","is-referenced-by-count":8,"title":["Neuropeptide Calcitonin Gene-Related Peptide Promotes Immune Homeostasis of Bacterial Meningitis by Inducing Major Histocompatibility Complex Class II Ubiquitination"],"prefix":"10.1093","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9547-1838","authenticated-orcid":false,"given":"Yuxiang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neuroimmune and Antibody Engineering, Beijing Institute of Basic Medical Sciences , Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanying","family":"Wang","sequence":"additional","affiliation":[{"name":"Joint National Laboratory for Antibody Drug Engineering, School of Medicine, Henan University , Kaifeng"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neuroimmune and Antibody Engineering, Beijing Institute of Basic Medical Sciences , Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Joint National Laboratory for Antibody Drug Engineering, School of Medicine, Henan University , Kaifeng"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neuroimmune and Antibody Engineering, Beijing Institute of Basic Medical Sciences , Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neuroimmune and Antibody Engineering, Beijing Institute of Basic Medical Sciences , Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neuroimmune and Antibody Engineering, Beijing Institute of Basic Medical Sciences , Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-1359","authenticated-orcid":false,"given":"Zhiding","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neuroimmune and Antibody Engineering, Beijing Institute of Basic Medical Sciences , Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese People\u2019s Liberation Army General Hospital , Beijing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gencheng","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neuroimmune and Antibody Engineering, Beijing Institute of Basic Medical Sciences , 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