{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:03:46Z","timestamp":1788411826784,"version":"build-2803163510"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The sporadic occurrence of human infections with swine-origin influenza A(H3N2) viruses and the continual emergence of novel A(H3N2) viruses in swine herds underscore the necessity for ongoing assessment of the pandemic risk posed by these viruses. Here, we selected 3 recent novel swine-origin A(H3N2) viruses isolated between 2017 to 2020, bearing hemagglutinins from the 1990.1, 2010.1, or 2010.2 clades, and evaluated their ability to cause disease and transmit in a ferret model. We conclude that despite considerable genetic variances, all 3 contemporary swine-origin A(H3N2) viruses displayed a capacity for robust replication in the ferret respiratory tract and were also capable of limited airborne transmission. These findings highlight the continued public health risk of swine-origin A(H3N2) strains, especially in human populations with low cross-reactive immunity.<\/jats:p>","DOI":"10.1093\/infdis\/jiad359","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T10:25:12Z","timestamp":1692613512000},"page":"1107-1111","source":"Crossref","is-referenced-by-count":8,"title":["Pathogenesis and Transmission Assessment of 3 Swine-Origin Influenza A(H3N2) Viruses With Zoonotic Risk to Humans Isolated in the United States, 2017\u20132020"],"prefix":"10.1093","volume":"229","author":[{"given":"Xiangjie","family":"Sun","sequence":"first","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A","family":"Belser","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna A","family":"Pulit-Penaloza","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Brock","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pappas","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natosha","family":"Zanders","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunho","family":"Jang","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Jones","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence M","family":"Tumpey","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Todd","family":"Davis","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-6724","authenticated-orcid":false,"given":"Taronna R","family":"Maines","sequence":"additional","affiliation":[{"name":"Influenza Division, Centers for Disease Control and Prevention , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"2024041213293441300_jiad359-B1","author":"Centers for Disease Control and Prevention"},{"key":"2024041213293441300_jiad359-B2","doi-asserted-by":"crossref","first-page":"e0099421","DOI":"10.1128\/msphere.00994-21","article-title":"Genetic and antigenic characterization of an expanding H3 influenza a virus clade in U.S. swine visualized by Nextstrain","volume":"7","author":"Neveau","year":"2022","journal-title":"mSphere"},{"key":"2024041213293441300_jiad359-B3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1186\/s12859-018-2408-7","article-title":"ISU FLUture: a veterinary diagnostic laboratory web-based platform to monitor the temporal genetic patterns of influenza A virus in swine","volume":"19","author":"Zeller","year":"2018","journal-title":"BMC Bioinformatics"},{"key":"2024041213293441300_jiad359-B4","doi-asserted-by":"crossref","first-page":"veab090","DOI":"10.1093\/ve\/veab090","article-title":"Spatial and temporal coevolution of N2 neuraminidase and H1 and H3 hemagglutinin genes of influenza A virus in US swine","volume":"7","author":"Zeller","year":"2021","journal-title":"Virus Evol"},{"key":"2024041213293441300_jiad359-B5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/1040638720907918","article-title":"Detection of live attenuated influenza vaccine virus and evidence of reassortment in the U. 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