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The high mortality and increasing frequency and magnitude of recent outbreaks along with the increased potential for spread from rural to urban areas highlight the importance of pandemic preparedness for these viruses. Despite their designation as high-priority pathogens, numerous scientific gaps exist in critical areas. In this review, these gaps and an assessment of potential prototype pathogen candidates are presented for this important virus family.<\/jats:p>","DOI":"10.1093\/infdis\/jiad362","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:18:54Z","timestamp":1697609934000},"page":"S446-S459","source":"Crossref","is-referenced-by-count":28,"title":["Filoviruses: Scientific Gaps and Prototype Pathogen Recommendation"],"prefix":"10.1093","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3796-6760","authenticated-orcid":false,"given":"Lesley C","family":"Dupuy","sequence":"first","affiliation":[{"name":"Virology Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina F","family":"Spiropoulou","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6473-3049","authenticated-orcid":false,"given":"Jonathan S","family":"Towner","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R","family":"Spengler","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J","family":"Sullivan","sequence":"additional","affiliation":[{"name":"National Emerging Infectious Diseases Laboratories, Boston University , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"2024041206150071200_jiad362-B1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1099\/jgv.0.001252","article-title":"ICTV virus taxonomy profile: filoviridae","volume":"100","author":"Kuhn","year":"2019","journal-title":"J Gen 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