{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:50:46Z","timestamp":1771627846766,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AI060699"],"award-info":[{"award-number":["P01 AI060699"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI129269"],"award-info":[{"award-number":["R01 AI129269"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RC2 DK124207"],"award-info":[{"award-number":["RC2 DK124207"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK115791"],"award-info":[{"award-number":["R01 DK115791"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12 HD27748"],"award-info":[{"award-number":["K12 HD27748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AI007260"],"award-info":[{"award-number":["T32 AI007260"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>While the immunogenicity of SARS-CoV-2 vaccines has been well described in adults, pediatric populations have been less studied. In particular, children with type 1 diabetes are generally at elevated risk for more severe disease after infections, but are understudied in terms of COVID-19 and SARS-CoV-2 vaccine responses. We investigated the immunogenicity of COVID-19 mRNA vaccinations in 35 children with type 1 diabetes (T1D) and 23 controls and found that these children develop levels of SARS-CoV-2 neutralizing antibody titers and spike protein-specific T cells comparable to nondiabetic children. However, in comparing the neutralizing antibody responses in children who received 2 doses of mRNA vaccines (24 T1D; 14 controls) with those who received a third, booster dose (11 T1D; 9 controls), we found that the booster dose increased neutralizing antibody titers against ancestral SARS-CoV-2 strains but, unexpectedly, not Omicron lineage variants. In contrast, boosting enhanced Omicron variant neutralizing antibody titers in adults.<\/jats:p>","DOI":"10.1093\/infdis\/jiad366","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T18:50:16Z","timestamp":1692989416000},"page":"1059-1067","source":"Crossref","is-referenced-by-count":1,"title":["Monovalent SARS-CoV-2 mRNA Vaccine Does not Boost Omicron-Specific Immune Response in Diabetic and Control Pediatric Patients"],"prefix":"10.1093","volume":"229","author":[{"given":"Alan","family":"Sariol","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Iowa , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly A","family":"Vickers","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Iowa , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon M","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics-Endocrinology and Diabetes, University of Iowa , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Weiskopf","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology , La Jolla, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology , La Jolla, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew W","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Pediatrics-Endocrinology and Diabetes, University of Iowa , Iowa City, Iowa , USA"},{"name":"Fraternal Order of Eagles Diabetes Research Center, University of Iowa , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"Tansey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics-Endocrinology and Diabetes, University of Iowa , Iowa City, Iowa , USA"},{"name":"Fraternal Order of Eagles Diabetes Research Center, University of Iowa , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherina T","family":"Pinnaro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics-Endocrinology and Diabetes, University of Iowa , Iowa City, Iowa , USA"},{"name":"Fraternal Order of Eagles Diabetes Research Center, University of Iowa , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-2354","authenticated-orcid":false,"given":"Stanley","family":"Perlman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Iowa , Iowa City, Iowa , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"2024041213281002300_jiad366-B1","author":"World Health Organization"},{"key":"2024041213281002300_jiad366-B2","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMc2003717","article-title":"Detection of COVID-19 in children in early January 2020 in Wuhan, China","volume":"382","author":"Liu","year":"2020","journal-title":"N Engl J Med"},{"key":"2024041213281002300_jiad366-B3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.15585\/mmwr.mm7107e4","article-title":"Hospitalizations of children and adolescents with laboratory-confirmed COVID-19\u2014COVID-NET, 14 states, July 2021-January 2022","volume":"71","author":"Marks","year":"2022","journal-title":"MMWR Morb Mortal Wkly 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