{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T22:47:02Z","timestamp":1771454822435,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2016\/01735-2"],"award-info":[{"award-number":["2016\/01735-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2019\/13713-1"],"award-info":[{"award-number":["2019\/13713-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In 2018 there was a large yellow fever outbreak in S\u00e3o Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, hemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin 2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe cases and provide care to improve disease outcome.<\/jats:p>","DOI":"10.1093\/infdis\/jiad389","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T08:23:53Z","timestamp":1694766233000},"page":"e60-e64","source":"Crossref","is-referenced-by-count":10,"title":["Levels of Angiopoietin 2 Are Predictive for Mortality in Patients Infected With Yellow Fever Virus"],"prefix":"10.1093","volume":"230","author":[{"given":"Cornelia A M","family":"van de Weg","sequence":"first","affiliation":[{"name":"Medical Investigation Laboratory 60, School of Medicine, University of S\u00e3o Paulo , Brazil"},{"name":"Department of Internal Medicine, Erasmus Medical Center , Rotterdam , the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1527-6910","authenticated-orcid":false,"given":"Mateus V","family":"Thomazella","sequence":"additional","affiliation":[{"name":"Medical Investigation Laboratory 60, School of Medicine, University of S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana P","family":"Marmorato","sequence":"additional","affiliation":[{"name":"Medical Investigation Laboratory 60, School of Medicine, University of S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina A","family":"Correia","sequence":"additional","affiliation":[{"name":"Medical Investigation Laboratory 60, School of Medicine, University of S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Z C","family":"Dias","sequence":"additional","affiliation":[{"name":"Medical Investigation Laboratory 60, School of Medicine, University of S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvino","family":"Maestri","sequence":"additional","affiliation":[{"name":"Medical Investigation Laboratory 60, School of Medicine, University of S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz G F A B E","family":"Zanella","sequence":"additional","affiliation":[{"name":"Medical Investigation Laboratory 60, School of Medicine, University of S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia B","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"School of Medicine, Hospital das Cl\u00ednicas , S\u00e3\u200co Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvina C","family":"F\u00e9lix","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, University of S\u00e3o Paulo , S\u00e3o Paulo, Brazil\u200c"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos H V","family":"Moreira","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute \u201cEm\u00edlio Ribas\u201d , S\u00e3o Paulo, Brazil\u200c"},{"name":"Department of Infectious and Parasitic Diseases, School of Medicine, University of S\u00e3o Paulo , Brazil"},{"name":"Department of HIV, Infectious Diseases and Global Medicine, University of California , San Francisco"},{"name":"Zuckerberg San Francisco General Hospital , California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Buccheri","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute \u201cEm\u00edlio Ribas\u201d , S\u00e3o Paulo, Brazil\u200c"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla R","family":"Costa","sequence":"additional","affiliation":[{"name":"Medical Investigation Laboratory 60, School of Medicine, University of S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esper G","family":"Kall\u00e1s","sequence":"additional","affiliation":[{"name":"Medical Investigation Laboratory 60, School of Medicine, University of S\u00e3o Paulo , 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