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Three serologic assays\u2014virus-like particle binding, histoblood group antigen blocking, and neutralizing\u2014were performed for each genotype. Results were highly correlated within a genotype but not between genotypes. Although the vaccine provided protection from GII.2-associated disease, little GII.2-specific neutralization occurred after vaccination. Choice of antibody assay can affect assessments of human norovirus vaccine immunogenicity.<\/jats:p>","DOI":"10.1093\/infdis\/jiad401","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:29:13Z","timestamp":1696238953000},"page":"1402-1407","source":"Crossref","is-referenced-by-count":16,"title":["A Bivalent Human Norovirus Vaccine Induces Homotypic and Heterotypic Neutralizing Antibodies"],"prefix":"10.1093","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9989-6772","authenticated-orcid":false,"given":"Robert L","family":"Atmar","sequence":"first","affiliation":[{"name":"Department of Medicine"},{"name":"Department of Molecular Virology and Microbiology, Baylor College of Medicine , Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-4693","authenticated-orcid":false,"given":"Khalil","family":"Ettayebi","sequence":"additional","affiliation":[{"name":"Department of 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