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Replicating IAV induced a more robust interferon response than SARS-CoV-2 and suppressed SARS-CoV-2 replication in both sequential and simultaneous infections, whereas SARS-CoV-2 did not enhance host cell defense during influenza infection or suppress IAV replication. Oseltamivir, an antiviral targeting influenza, reduced IAV replication during coinfection but also reduced the host antiviral response and restored SARS-CoV-2 replication. These results demonstrate how perturbations in one viral infection can impact its effect on a coinfecting virus.<\/jats:p>","DOI":"10.1093\/infdis\/jiad402","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:30Z","timestamp":1695081630000},"page":"1430-1434","source":"Crossref","is-referenced-by-count":32,"title":["Viral Interference During Influenza A\u2013SARS-CoV-2 Coinfection of the Human Airway Epithelium and Reversal by Oseltamivir"],"prefix":"10.1093","volume":"229","author":[{"given":"Nagarjuna R","family":"Cheemarla","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Yale School of Medicine , New Haven, Connecticut , USA"},{"name":"Department of Immunobiology, Yale School of Medicine , New Haven, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale School of 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