{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:13:56Z","timestamp":1765995236380,"version":"3.37.3"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"publisher","award":["784721"],"award-info":[{"award-number":["784721"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010805","name":"Medical Research Council of Southeast Sweden","doi-asserted-by":"publisher","award":["852511"],"award-info":[{"award-number":["852511"]}],"id":[{"id":"10.13039\/100010805","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Futurum\u2013the Academy of Health and Welfare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lyme neuroborreliosis (LNB) is a complex neuroinflammatory disorder caused by Borrelia burgdorferi, which is transmitted through tick bites. Epigenetic alterations, specifically DNA methylation (DNAm), could play a role in the host immune response during infection. In this study, we present the first genome-wide analysis of DNAm in peripheral blood mononuclear cells from patients with LNB and those without LNB. Using a network-based approach, we highlighted HLA genes at the core of these DNAm changes, which were found to be enriched in immune-related pathways. These findings shed light on the role of epigenetic modifications in the LNB pathogenesis that should be confirmed and further expanded upon in future studies.<\/jats:p>","DOI":"10.1093\/infdis\/jiad451","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T21:14:58Z","timestamp":1697145298000},"page":"1209-1214","source":"Crossref","is-referenced-by-count":4,"title":["Genome-wide DNA Methylation Profiling in Lyme Neuroborreliosis Reveals Altered Methylation Patterns of <i>HLA<\/i> Genes"],"prefix":"10.1093","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9315-8901","authenticated-orcid":false,"given":"Anna J","family":"Henningsson","sequence":"first","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine, County Hospital Ryhov , J\u00f6nk\u00f6ping"},{"name":"Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Link\u00f6ping University , Link\u00f6ping , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-7434","authenticated-orcid":false,"given":"Sandra","family":"Hellberg","sequence":"additional","affiliation":[{"name":"Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Link\u00f6ping University , Link\u00f6ping , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-9892","authenticated-orcid":false,"given":"Maria","family":"Lerm","sequence":"additional","affiliation":[{"name":"Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Link\u00f6ping University , Link\u00f6ping , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6048-775X","authenticated-orcid":false,"given":"Shumaila","family":"Sayyab","sequence":"additional","affiliation":[{"name":"Division of Inflammation and Infection, Department of 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