{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:37:03Z","timestamp":1785148623261,"version":"3.55.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Innovative Medicines Initiative 2 Joint Undertaking","award":["101034339"],"award-info":[{"award-number":["101034339"]}]},{"name":"Horizon 2020 Research and Innovation Programme"},{"DOI":"10.13039\/100013322","name":"European Federation of Pharmaceutical Industries and Associations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>During the first year of life, 1 in 4 infants develops a symptomatic respiratory syncytial virus (RSV) infection, yet only half seek medical attention. The current focus on medically attended RSV therefore underrepresents the true societal burden of RSV. We assessed the burden of nonmedically attended RSV infections and compared with medically attended RSV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed active RSV surveillance until the age of 1 year in a cohort (n = 993) nested within the Respiratory Syncytial Virus Consortium in EUrope (RESCEU) prospective birth cohort study enrolling healthy term-born infants in 5 European countries. Symptoms, medication use, wheezing, and impact on family life were analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>For 97 of 120 (80.1%) nonmedically attended RSV episodes, sufficient data were available for analysis. In 50.5% (49\/97), symptoms lasted \u226515 days. Parents reported impairment in usual daily activities in 59.8% (58\/97) of episodes; worries, 75.3% (73\/97); anxiety, 34.0% (33\/97); and work absenteeism, 10.8% (10\/93). Compared with medically attended RSV (n = 102, 9 hospital admissions), Respiratory Syncytial Virus NETwork (ReSViNET) severity scores were lower (3.5 vs 4.6, P &amp;lt; .001), whereas duration of respiratory symptoms and was comparable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Even when medical attendance is not required, RSV infection poses a substantial burden to infants, families, and society. These findings are important for policy makers when considering the implementation of RSV immunization.<\/jats:p>\n                  <jats:p>Clinical Trials Registration. ClinicalTrials.gov (NCT03627572).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/infdis\/jiad477","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:53:56Z","timestamp":1699404836000},"page":"S40-S50","source":"Crossref","is-referenced-by-count":15,"title":["Substantial Burden of Nonmedically Attended RSV Infection in Healthy-Term Infants: An International Prospective Birth Cohort Study"],"prefix":"10.1093","volume":"229","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7164-2014","authenticated-orcid":false,"given":"Sarah F","family":"Hak","sequence":"first","affiliation":[{"name":"Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1446-9614","authenticated-orcid":false,"given":"Roderick P","family":"Venekamp","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0951-9744","authenticated-orcid":false,"given":"Marie-No\u00eblle","family":"Billard","sequence":"additional","affiliation":[{"name":"Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5942-8082","authenticated-orcid":false,"given":"Marlies A","family":"van Houten","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Spaarne Gasthuis , Hoofddorp and Haarlem , the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Pollard","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6504-0116","authenticated-orcid":false,"given":"Terho","family":"Heikkinen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Turku and Turku University Hospital , Turku , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research, University of Edinburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Millar","sequence":"additional","affiliation":[{"name":"Children's Clinical Research Facility, NHS Lothian , Edinburgh , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-581X","authenticated-orcid":false,"given":"Federico","family":"Martin\u00f3n-Torres","sequence":"additional","affiliation":[{"name":"Genetics, Vaccines and Infections Research Group, Instituto de Investigaci\u00f3n Sanitaria de Santiago, University of Santiago de Compostela , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8803-957X","authenticated-orcid":false,"given":"Ana","family":"Dacosta-Urbieta","sequence":"additional","affiliation":[{"name":"Genetics, Vaccines and Infections Research Group, Instituto de Investigaci\u00f3n Sanitaria de Santiago, University of Santiago de Compostela , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-4475","authenticated-orcid":false,"given":"Louis J","family":"Bont","sequence":"additional","affiliation":[{"name":"Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne G","family":"Wildenbeest","sequence":"additional","affiliation":[{"name":"Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PROMISE Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick","family":"Venekamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Wildenbeest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-No\u00eblle","family":"Billard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"van Houten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Bont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Dacosta-Urbieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Martin\u00f3n-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terho","family":"Heikkinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Openshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Beutels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Nohynek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Teirlinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Paget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Kragten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Giaquinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Diez-Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Mikolajczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gael","family":"Dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin Tin","family":"Htar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Aerssens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Vernhes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Ahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Molero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"2024030105201165200_jiad477-B1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S2213-2600(22)00414-3","article-title":"The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study","volume":"11","author":"Wildenbeest","year":"2023","journal-title":"Lancet Respir Med"},{"key":"2024030105201165200_jiad477-B2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jinf.2019.09.002","article-title":"Respiratory syncytial virus infections in children 0\u201324 months of age in the community","volume":"80","author":"Toivonen","year":"2020","journal-title":"J Infect"},{"key":"2024030105201165200_jiad477-B3","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1186\/s12879-021-06629-z","article-title":"The impact of childhood RSV infection on children's and parents\u2019 quality of life: a prospective multicenter study in Spain","volume":"21","author":"D\u00edez-Gand\u00eda","year":"2021","journal-title":"BMC Infect Dis"},{"key":"2024030105201165200_jiad477-B4","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/infdis\/jiaa754","article-title":"Burden of respiratory syncytial virus infection during the first year of life","volume":"223","author":"Thomas","year":"2021","journal-title":"J Infect Dis"},{"key":"2024030105201165200_jiad477-B5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/infdis\/jiw475","article-title":"Clinical and socioeconomic burden of respiratory syncytial virus infection in children","volume":"215","author":"Heikkinen","year":"2017","journal-title":"J Infect Dis"},{"key":"2024030105201165200_jiad477-B6","first-page":"1244","article-title":"Economic-burden trajectories in commercially insured US infants with respiratory syncytial virus infection","volume":"221","author":"Chirikov","year":"2020","journal-title":"J Infect Dis"},{"key":"2024030105201165200_jiad477-B7","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1001\/archpediatrics.2011.1669","article-title":"Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis","volume":"166","author":"Mansbach","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2024030105201165200_jiad477-B8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1553-2712.2007.00034.x","article-title":"Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department","volume":"15","author":"Mansbach","year":"2008","journal-title":"Acad Emerg Med"},{"key":"2024030105201165200_jiad477-B9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/irv.12686","article-title":"Estimates for quality of life loss due to respiratory syncytial virus","volume":"14","author":"Hodgson","year":"2020","journal-title":"Influenza Other Respir Viruses"},{"issue":"suppl 2","key":"2024030105201165200_jiad477-B10","doi-asserted-by":"crossref","first-page":"S236","DOI":"10.1093\/infdis\/jiac183","article-title":"Impact of respiratory syncytial virus on child, caregiver, and family quality of life in the United States: systematic literature review and analysis","volume":"226","author":"Glaser","year":"2022","journal-title":"J Infect Dis"},{"key":"2024030105201165200_jiad477-B11","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1016\/j.vaccine.2023.03.024","article-title":"Economic burden and health-related quality-of-life among infants with respiratory syncytial virus infection: a multi-country prospective cohort study in Europe","volume":"41","author":"Mao","year":"2023","journal-title":"Vaccine"},{"key":"2024030105201165200_jiad477-B12","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1016\/S1473-3099(22)00291-2","article-title":"Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape","volume":"23","author":"Mazur","year":"2023","journal-title":"Lancet Infect Dis"},{"issue":"suppl 7","key":"2024030105201165200_jiad477-B13","doi-asserted-by":"crossref","first-page":"S606","DOI":"10.1093\/infdis\/jiaa310","article-title":"Respiratory Syncytial Virus Consortium in Europe (RESCEU) birth cohort study: defining the burden of infant respiratory syncytial virus disease in Europe","volume":"222","author":"Wildenbeest","year":"2020","journal-title":"J Infect Dis"},{"key":"2024030105201165200_jiad477-B14","doi-asserted-by":"crossref","first-page":"e0157665","DOI":"10.1371\/journal.pone.0157665","article-title":"Development and validation of a new clinical scale for infants with acute respiratory infection: the ReSViNET Scale","volume":"11","author":"Justicia-Grande","year":"2016","journal-title":"PLoS One"},{"key":"2024030105201165200_jiad477-B15","author":"EuroQol Research Foundation"},{"key":"2024030105201165200_jiad477-B16","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1097\/INF.0b013e31829061e8","article-title":"Association between respiratory syncytial virus hospitalizations in infants and respiratory sequelae: systematic review and meta-analysis","volume":"32","author":"R\u00e9gnier","year":"2013","journal-title":"Ped Infect Dis J"},{"key":"2024030105201165200_jiad477-B17","doi-asserted-by":"crossref","first-page":"e13741","DOI":"10.1111\/pai.13741","article-title":"The role of respiratory syncytial virus- and rhinovirus-induced bronchiolitis in recurrent wheeze and asthma\u2014a systematic review and meta-analysis","volume":"33","author":"Makrinioti","year":"2022","journal-title":"Ped Allergy Immunol"},{"key":"2024030105201165200_jiad477-B18","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s42770-022-00742-0","article-title":"Respiratory syncytial virus: viral load, viral decay, and disease progression in children with bronchiolitis","volume":"53","author":"Watanabe","year":"2022","journal-title":"Braz J Microbiol"},{"key":"2024030105201165200_jiad477-B19","doi-asserted-by":"crossref","first-page":"010426","DOI":"10.7189\/jogh.10.010426","article-title":"The role of viral co-infections in the severity of acute respiratory infections among children infected with respiratory syncytial virus (RSV): a systematic review and meta-analysis","volume":"10","author":"Li","year":"2020","journal-title":"J Glob Health"},{"key":"2024030105201165200_jiad477-B20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/infdis\/jiw483","article-title":"The outpatient burden of respiratory syncytial virus infections in older children","volume":"215","author":"Sim\u00f5es","year":"2017","journal-title":"J Infect Dis"},{"key":"2024030105201165200_jiad477-B21","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1056\/NEJMoa2110275","article-title":"Nirsevimab for prevention of RSV in healthy late-preterm and term infants","volume":"386","author":"Hammitt","year":"2022","journal-title":"N Engl J Med"},{"key":"2024030105201165200_jiad477-B22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s40265-022-01829-6","article-title":"Nirsevimab: first approval","volume":"83","author":"Keam","year":"2023","journal-title":"Drugs"},{"key":"2024030105201165200_jiad477-B23","author":"Sanofi Canada"},{"key":"2024030105201165200_jiad477-B24","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1056\/NEJMoa2216480","article-title":"Bivalent prefusion F vaccine in pregnancy to prevent RSV illness in infants","volume":"388","author":"Kampmann","year":"2023","journal-title":"N Engl J Med"},{"key":"2024030105201165200_jiad477-B25","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jval.2022.11.014","article-title":"Cost-effectiveness of respiratory syncytial virus preventive interventions in children: a model comparison study","volume":"26","author":"Li","year":"2023","journal-title":"Value Health"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jid\/advance-article-pdf\/doi\/10.1093\/infdis\/jiad477\/53168342\/jiad477.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/229\/Supplement_1\/S40\/56808725\/jiad477.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jid\/article-pdf\/229\/Supplement_1\/S40\/56808725\/jiad477.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T05:22:59Z","timestamp":1709270579000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article\/229\/Supplement_1\/S40\/7342410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,3]]},"references-count":25,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2023,11,3]]},"published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/infdis\/jiad477","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3,15]]},"published":{"date-parts":[[2023,11,3]]}}}