{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:59:44Z","timestamp":1789340384954,"version":"build-2803163510"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003323","name":"ANRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]},{"name":"France Recherche Nord et Sud SIDA-HIV H\u00e9patites","award":["14730"],"award-info":[{"award-number":["14730"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSILs) in men who have sex with men living with human immunodeficiency virus and who underwent 3 visits over 2 years, with cytology and high-resolution anoscopy, within the ANRS-EP57-APACHES study. The cumulative HSIL detection rate was 33% (134 of 410), of which 48% HSILs were detected at baseline. HSIL detection varied considerably by center (from 13% to 51%). The strongest HSIL determinants were baseline human papillomavirus 16 (adjusted odds ratio, 8.2; 95% confidence interval, 3.6\u201318.9) and p16\/Ki67 (4.6 [2.3\u20139.1]). Repeated annual cytology and high-resolution anoscopy improved HSIL detection but did not fully compensate for between-center heterogeneity.<\/jats:p>","DOI":"10.1093\/infdis\/jiad506","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T11:08:43Z","timestamp":1700132923000},"page":"55-60","source":"Crossref","is-referenced-by-count":2,"title":["Cumulative Detection of Anal High-Grade Squamous Intraepithelial Lesions Over 2-Year Follow-up in Men Who Have Sex With Men Living With Human Immunodeficiency Virus in France"],"prefix":"10.1093","volume":"230","author":[{"given":"Jean-Damien","family":"Combes","sequence":"first","affiliation":[{"name":"International Agency for Research on Cancer (IARC\/WHO), Early Detection, Prevention, and Infections Branch , Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Didelot","sequence":"additional","affiliation":[{"name":"Service 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